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• W2331118346 abstract "We read with interest the publication in this journal by Aagard et al. 1 Aagard T. Roed C. Larsen A.R. Peterson A. Dahl B. Skinhøj et al. Long-term mortality after Staphylococcus aureus spondylodiscitis: a Danish nationwide population-based cohort study. J Infect. 2014; 69: 252-258 Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar which detailed long term mortality in adults diagnosed with Staphylococcus aureus spondylodiscitis. The authors found S. aureus spondylodiscitis to be associated with an increased risk of death, with impact on relative risk of mortality highest for patients in the youngest age quartile. 1 Aagard T. Roed C. Larsen A.R. Peterson A. Dahl B. Skinhøj et al. Long-term mortality after Staphylococcus aureus spondylodiscitis: a Danish nationwide population-based cohort study. J Infect. 2014; 69: 252-258 Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar In the absence of recent instrumentation of the spine, bacteraemia is a sine qua non of infective spondylodiscitis. Over the last decade in the United Kingdom the rate of methicillin-sensitive S. aureus has remained stable, however the rate of Gram negative bacteraemia (especially of Escherichia coli) has increased such that Gram negative bacteria now account for two thirds of all bacteraemias. Both S. aureus and E. coli bacteraemias affect elderly patients disproportionately. Estimates of the incidence of infective spondylodiscitis vary widely between 4 and 24 cases per million population annually, with a trend towards increasing incidence over time. 2 Digby J.M. Kersley J.B. Pyogenic non-tuberculous spinal infection: an analysis of thirty cases. J Bone Joint Surg. 1979; 61: 47-55 Google Scholar , 3 Krogsgaard M.R. Wagn P. Bengtsson J. Epidemiology of acute vertebral osteomyelitis in Denmark: 137 cases in Denmark 1978–1982, compared to cases reported to the National Patient Register 1991–1993. Acta Orthop Scand. 1998; 69: 513-517 Crossref PubMed Scopus (113) Google Scholar , 4 Beronius M. Bergman B. Andersson R. Vertebral osteomyelitis in Goteborg, Sweden: a retrospective study of patients during 1990–95. Scand J Infect Dis. 2001; 33: 527-532 Crossref PubMed Scopus (167) Google Scholar , 5 Hopkinson N. Stevenson J. Benjamin S. A case ascertainment study of septic discitis: clinical, microbiological and radiological features. QJM. 2001; 94: 465-470 Crossref PubMed Scopus (119) Google Scholar , 6 Grammatico L. Baron S. Rusch E. Lepage B. Surer N. Desenclos J.C. et al. Epidemiology of vertebral osteomyelitis (VO) in France: analysis of hospital-discharge data 2002–2003. Epidemiol Infect. 2008; 136: 653-660 Crossref PubMed Scopus (221) Google Scholar , 7 Chelsom J. Solberg C.O. Vertebral osteomyelitis at a Norwegian university hospital 1987–97: clinical features, laboratory findings and outcome. Scand J Infect Dis. 1998; 30: 147-151 Crossref PubMed Scopus (119) Google Scholar We work at Brighton and Sussex University Hospitals (BSUH) NHS Trust, an 800 bed acute hospital on the south coast of England serving a local population of approximately 500,000 people. We undertook a retrospective service evaluation of infective spondylodiscitis cases presenting to BSUH NHS Trust between January 2009 and August 2014 inclusive. Long-term mortality after Staphylococcus aureus spondylodiscitis: A Danish nationwide population-based cohort studyJournal of InfectionVol. 69Issue 3PreviewTo determine the long-term mortality and the causes of death after Staphylococcus aureus spondylodiscitis. Full-Text PDF" @default.
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• W2331118346 date "2016-07-01" @default.
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• W2331118346 title "An ageing population and changing UK bacteraemia profile may affect the characteristics and microbiology of infective spondylodiscitis" @default.
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• W2331118346 doi "https://doi.org/10.1016/j.jinf.2016.04.005" @default.
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