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• W2331138196 abstract "The present study was designed to examine the antitumor effect of hyperthermia alone in relation to the histopathological changes. Rabbit VX2 carcinoma was used in this study. Microwave hyperthermia (2, 450 MHz) was carried out at 41°C, 43°Cand 45°Cfor a 30-minute period. Measurement of temperature was obtained by thermister at the tumor center. The antitumor effect was determined by comparing the growth curve of VX2 carcinoma which was obtained by tumor volume calculated from tumor width after heating. Tumor angiography was performed immediately and 3, 24 and 72 hours after heating and the same specimens were observed histopathologically using Hematoxilin-Eosin stained sections.Consequently the antitumor effect was observed in the groups heated at 43°C and 45°C. In particular, the 45°C heated group showed a predominant antitumor effect. In the 41°C heated group, no antitumor effect was observed. With regard to tumor growth rate, it was relatively delayed in the 45°C heated group as compared to the 43°C heated group. In the 43°C and 45°C heated groups, tumor mitosis increased 72 hours after heating. Therefore, it was considered that recovery from damage tended to be later at higher temperatures. The histopathological changes of tumor cells after heating included pycnosis, karyorrhexis, karyolysis and eosinophilic degeneration and these changes tended to be remarkable in the tumor center rather than periphery. Tumor vessel damages showed thrombosis and dilatation of the vascular wall due to fibrin deposit. In the 45°C heated group, irreversible fibrinoid degeneration was additionaly observed. Though tumor vessel damage tended to continue as the temperature ascended, these changes were considered reversible because the contrast medium started flowing into these injured vessels with the passage of time. In the 45°C treated group, damage was observed in parts of normal vessels, therefore, the hyperthermic approach as considered to affect normal tissues at higher temperatures." @default.
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• W2331138196 date "1990-01-01" @default.
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• W2331138196 title "Studies on antitumor effect and hystopathological alteration following hyperthermia on VX2 carcinoma." @default.
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• W2331138196 doi "https://doi.org/10.5794/jjoms.36.56" @default.
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