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- W2331148778 abstract "Background: In 2009 international consensus group defined early cancers as vaguely nodules with stromal invasion (invasion into portal areas) without arterial vascularization. Although this consensus is reasonable, we don’t know clinical features of early cancers, e.g. how to diagnose early cancers or how early cancers develop. Stromal invasion means decreasing of portal areas and portal blood flow. Therefore we’ve investigated clinical features using Angio-CT system since 2000. Methods: We’ve followed 659 patients with chronic liver disease and detected 115 small HCCs of 61 patients. We’ve performed Angio-CT for these 115 HCCs, and observed until early cancers changed to typical HCCs. Results: 107 HCCs showed low attenuation on CTAP and high attenuation on CTHA (typical HCC). Only 8 nodules showed low on CTAP and not high on CTHA (early cancer). 2 of 8 showed low on CTAP and not high on CTHA were resected. Resected specimens showed typical early cancers. One was biopsied by needle and showed well-differentiated carcinoma. Others were observed until changed to typical HCCs by periodic Angio-CT examinations. Observation periods were 0.8–5.5 years. These 8 early cancers developed via multistep mechanism. However these early cancers increased slowly in size and did not metastasize. Conclusions: 1. Early cancers developed via multistep mechanism, however fewer than expected. 2. Small needle biopsy alone could not diagnose early cancers exactly. Low attenuation on CTAP and not high attenuation on CTHA is useful to diagnose early cancers. 3. We need a new consensus how to manage early cancers." @default.
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- W2331148778 date "2013-04-01" @default.
- W2331148778 modified "2023-09-28" @default.
- W2331148778 title "651 MICA PLAYS AN OPPOSITE ROLE IN HEPATOCARCINOGENESIS BETWEEN HEPATITIS B AND HEPATITIS C" @default.
- W2331148778 doi "https://doi.org/10.1016/s0168-8278(13)60653-4" @default.
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