FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2331176098> ?p ?o ?g. }

• W2331176098 endingPage "938" @default.
• W2331176098 startingPage "930" @default.
• W2331176098 abstract "The X-ray crystal structure of human S-adenosylhomocysteine (AdoHcy) hydrolase was first determined as a tetrameric form bound with the novel mechanism-based inhibitor fluoroneplanocin A (4b). The crystallized enzyme complex showed the closed conformation and turned out to be the intermediate of mechanism-based inhibition. It confirmed that the cofactor depletion by 3'-oxidation of fluoroneplanocin A contributes to the enzyme inhibition along with the irreversible covalent modification of AdoHcy hydrolase. In addition, a series of haloneplanocin A analogues (4b-e and 5b-e) were designed and synthesized to characterize the binding role and reactivity of the halogen substituents and the 4'-CH(2)OH group. The biological evaluation and molecular modeling studies identified the key pharmacophores and structural requirements for the inhibitor binding of AdoHcy hydrolase. The inhibitory activity was decreased as the size of the halogen atom increased and/or if the 4'-CH(2)OH group was absent. These results could be utilized to design new therapeutic agents operating via AdoHcy hydrolase inhibition." @default.
• W2331176098 created "2016-06-24" @default.
• W2331176098 creator A5000045048 @default.
• W2331176098 creator A5006225135 @default.
• W2331176098 creator A5024107695 @default.
• W2331176098 creator A5033401506 @default.
• W2331176098 creator A5036976192 @default.
• W2331176098 creator A5039708869 @default.
• W2331176098 creator A5042122089 @default.
• W2331176098 creator A5045383471 @default.
• W2331176098 creator A5048108993 @default.
• W2331176098 creator A5052727791 @default.
• W2331176098 creator A5058073223 @default.
• W2331176098 creator A5064356448 @default.
• W2331176098 date "2011-01-12" @default.
• W2331176098 modified "2023-10-16" @default.
• W2331176098 title "X-ray Crystal Structure and Binding Mode Analysis of Human <i>S</i>-Adenosylhomocysteine Hydrolase Complexed with Novel Mechanism-Based Inhibitors, Haloneplanocin A Analogues" @default.
• W2331176098 cites W143581076 @default.
• W2331176098 cites W1539796472 @default.
• W2331176098 cites W1571312504 @default.
• W2331176098 cites W1763383961 @default.
• W2331176098 cites W1974231442 @default.
• W2331176098 cites W1977937919 @default.
• W2331176098 cites W1985220993 @default.
• W2331176098 cites W1993244734 @default.
• W2331176098 cites W1995017064 @default.
• W2331176098 cites W1996071843 @default.
• W2331176098 cites W1999275302 @default.
• W2331176098 cites W2005035347 @default.
• W2331176098 cites W2018620726 @default.
• W2331176098 cites W2031308714 @default.
• W2331176098 cites W2061776255 @default.
• W2331176098 cites W2082103614 @default.
• W2331176098 cites W2084789101 @default.
• W2331176098 cites W2103122705 @default.
• W2331176098 cites W2104705317 @default.
• W2331176098 cites W2105731033 @default.
• W2331176098 cites W2144081223 @default.
• W2331176098 cites W2157516695 @default.
• W2331176098 cites W2162323652 @default.
• W2331176098 cites W2172362106 @default.
• W2331176098 cites W2287976672 @default.
• W2331176098 cites W4293247451 @default.
• W2331176098 doi "https://doi.org/10.1021/jm1010836" @default.
• W2331176098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21226494" @default.
• W2331176098 hasPublicationYear "2011" @default.
• W2331176098 type Work @default.
• W2331176098 sameAs 2331176098 @default.
• W2331176098 citedByCount "30" @default.
• W2331176098 countsByYear W23311760982012 @default.
• W2331176098 countsByYear W23311760982013 @default.
• W2331176098 countsByYear W23311760982014 @default.
• W2331176098 countsByYear W23311760982015 @default.
• W2331176098 countsByYear W23311760982017 @default.
• W2331176098 countsByYear W23311760982018 @default.
• W2331176098 countsByYear W23311760982019 @default.
• W2331176098 countsByYear W23311760982020 @default.
• W2331176098 countsByYear W23311760982021 @default.
• W2331176098 countsByYear W23311760982022 @default.
• W2331176098 countsByYear W23311760982023 @default.
• W2331176098 crossrefType "journal-article" @default.
• W2331176098 hasAuthorship W2331176098A5000045048 @default.
• W2331176098 hasAuthorship W2331176098A5006225135 @default.
• W2331176098 hasAuthorship W2331176098A5024107695 @default.
• W2331176098 hasAuthorship W2331176098A5033401506 @default.
• W2331176098 hasAuthorship W2331176098A5036976192 @default.
• W2331176098 hasAuthorship W2331176098A5039708869 @default.
• W2331176098 hasAuthorship W2331176098A5042122089 @default.
• W2331176098 hasAuthorship W2331176098A5045383471 @default.
• W2331176098 hasAuthorship W2331176098A5048108993 @default.
• W2331176098 hasAuthorship W2331176098A5052727791 @default.
• W2331176098 hasAuthorship W2331176098A5058073223 @default.
• W2331176098 hasAuthorship W2331176098A5064356448 @default.
• W2331176098 hasConcept C107824862 @default.
• W2331176098 hasConcept C115624301 @default.
• W2331176098 hasConcept C142724271 @default.
• W2331176098 hasConcept C181199279 @default.
• W2331176098 hasConcept C185592680 @default.
• W2331176098 hasConcept C197957613 @default.
• W2331176098 hasConcept C204787440 @default.
• W2331176098 hasConcept C2776910235 @default.
• W2331176098 hasConcept C2780120296 @default.
• W2331176098 hasConcept C41183919 @default.
• W2331176098 hasConcept C55493867 @default.
• W2331176098 hasConcept C56173144 @default.
• W2331176098 hasConcept C71240020 @default.
• W2331176098 hasConcept C71924100 @default.
• W2331176098 hasConcept C8010536 @default.
• W2331176098 hasConceptScore W2331176098C107824862 @default.
• W2331176098 hasConceptScore W2331176098C115624301 @default.
• W2331176098 hasConceptScore W2331176098C142724271 @default.
• W2331176098 hasConceptScore W2331176098C181199279 @default.
• W2331176098 hasConceptScore W2331176098C185592680 @default.
• W2331176098 hasConceptScore W2331176098C197957613 @default.
• W2331176098 hasConceptScore W2331176098C204787440 @default.
• W2331176098 hasConceptScore W2331176098C2776910235 @default.
• W2331176098 hasConceptScore W2331176098C2780120296 @default.
• W2331176098 hasConceptScore W2331176098C41183919 @default.

• next