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- W2331191058 endingPage "134" @default.
- W2331191058 startingPage "125" @default.
- W2331191058 abstract "Apolipoprotein A-IV is a 46kDa glycoprotein that is synthesized by intestinal enterocytes and is incorporated into the surface of nascent chylomicrons. Considerable evidence suggests that apolipoprotein A-IV plays a role in intestinal lipid absorption and chylomicron assembly. We have proposed that polymorphisms that alter the interfacial behavior of apolipoprotein A-IV may modulate the physical properties and metabolic fate of plasma chylomicrons. Of the reported genetic polymorphisms of apolipoprotein A-IV, two, Q360H and T347S, are known to occur at high frequencies among the world populations. Biophysical studies have established that the Q360H isoprotein displays higher lipid affinity; conversely the T347S isoprotein is predicted to be less lipid avid. Recent studies have shown that the Q360H polymorphism is associated with increased postprandial hypertriglyceridemia, a reduced low-density lipoprotein response to dietary cholesterol in the setting of a moderate fat intake, an increased high-density lipoprotein response to changes in total dietary fat content, and lower body mass and adiposity; the T347S polymorphism appears to confer the opposite effects. Studies on the diet-gene interactions of other apolipoprotein A-IV alleles are needed, as are studies on the interactions between apolipoprotein A-IV alleles and other apolipoprotein polymorphisms." @default.
- W2331191058 created "2016-06-24" @default.
- W2331191058 creator A5062615822 @default.
- W2331191058 date "2002-04-01" @default.
- W2331191058 modified "2023-09-25" @default.
- W2331191058 title "Apolipoprotein A-IV polymorphisms and diet-gene interactions" @default.
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- W2331191058 doi "https://doi.org/10.1097/00041433-200204000-00003" @default.
- W2331191058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11891414" @default.
- W2331191058 hasPublicationYear "2002" @default.
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