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- W2331194932 abstract "It is highly desirable to develop a strategy to directly target cancer cells with chemotherapeutic agents in cancer treatment regimens. Targeted cancer therapies that can selectively kill cancer cells without harming other cells in the body would represent a major improvement in the clinical treatment of cancer. This would lead to reduction or elimination of toxic side effects, more efficient delivery of the drug to the targeted site, and potentially reduce dosage of the administered drug and a resulting decrease in toxicity to healthy cells and in the cost of the chemotherapeutic regimen. Arbor Therapeutics has developed an anticancer technology that combines proprietary anticancer prodrugs, nanotechnology, and knowledge of human physiology. Tumors have a voracious appetite for cholesterol which facilitates tumor growth and fuels their proliferation. We have transformed this need into a stealth delivery system to disguise and deliver anticancer drugs with the assistance of both the human body and the tumor cell. Arbor's novel chemotherapy strategy of selective stealth delivery of anticancer drugs is a combination of propriety prodrug assembled within a pseudo-LDL-nanoparticle recognized by the body as a delivery structure for cholesterol and selectively delivered to cholesterol hungry tumor tissues via their over expression of LDL receptors. This selectivity with the attendant lowered side effect toxicity and potentially greater efficacy will provide significant patient benefit with increased patient retention (fewer dropouts), more rapid patient recovery due to less systemic drug toxicity, and better quality of life for patients undergoing therapy." @default.
- W2331194932 created "2016-06-24" @default.
- W2331194932 creator A5073868002 @default.
- W2331194932 date "2014-07-14" @default.
- W2331194932 modified "2023-09-25" @default.
- W2331194932 title "Enhancing the safety and efficacy of cancer" @default.
- W2331194932 doi "https://doi.org/10.1055/s-0034-1382323" @default.
- W2331194932 hasPublicationYear "2014" @default.
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