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• W2331240328 abstract "Background Binge alcohol (ethanol [EtOH]) drinking is common during adolescence, a time characterized by many behavioral and neurobiological changes. Among them, the GABA A receptor system undergoes substantial modifications, including changes in the density, distribution, and subunit composition of the receptor. Based on its demonstrated role in EtOH consumption, this study aimed to investigate the effects of 2 different GABA A receptor agonists on binge‐like EtOH intake in adolescent and adult mice using the Drinking‐in‐the‐Dark model. Methods Three hours into their dark cycle, adolescent (postnatal day 28 [P28]) and adult (P63) male C57 BL /6J mice were given daily access to 20% EtOH for 2 hours during 8 consecutive days. Immediately before the access on day 8, mice (P35 and P70) were systemically injected with 1 of 2 different GABA ergic drugs. The effects of muscimol, a full GABA A agonist, were assessed in a first experiment. The second experiment tested for the more specific involvement of δ ‐containing extrasynaptic GABA A receptors through the administration of THIP (4,5,6,7‐tetrahydroisoxazolo(5,4‐c)pyridin‐3‐ol). Results Adolescent mice consumed more EtOH than their adult counterparts. Following the administration of GABA A agonists, levels of EtOH intake were reduced at both ages. However, age‐dependent differences were revealed following the administration of THIP , with adolescents exhibiting greater sensitivity to its suppressant effects, especially during the first 30 minutes of binge EtOH access. Conclusions This study adds to the existing literature demonstrating the crucial role of the GABA A receptor in alcohol consumption. In addition, it suggests that age differences in the GABA A receptor modulation of binge alcohol drinking might be more dependent on extrasynaptic GABA A receptors." @default.
• W2331240328 created "2016-06-24" @default.
• W2331240328 creator A5016812902 @default.
• W2331240328 creator A5037287232 @default.
• W2331240328 date "2016-02-01" @default.
• W2331240328 modified "2023-09-27" @default.
• W2331240328 title "Involvement of the GABA_AReceptor in Age-Dependent Differences in Binge-Like Ethanol Intake" @default.
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• W2331240328 doi "https://doi.org/10.1111/acer.12953" @default.
• W2331240328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26833274" @default.
• W2331240328 hasPublicationYear "2016" @default.
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