Matches in SemOpenAlex for { <https://semopenalex.org/work/W2331273746> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2331273746 endingPage "96" @default.
- W2331273746 startingPage "95" @default.
- W2331273746 abstract "The renin angiotensin-aldosterone system (RAAS) and lipoxins (LXs) have similar roles in many processes. We previously reported that BML-111, a Lipoxin receptor agonist, inhibited chronic injury hepatic fibrosis by regulating RAAS, but whether LXs are involved in BML-111-mediated protection from acute injury is unclear still.We established models of acute liver/lung injury and confirmed them with histopathology and myeloperoxidase (MPO) measurements. BML-111, a lipoxin receptor agonist, was applied to mimic the effects of LXs. The contents and activities of angiotensin converting enzyme(ACE) and angiotensinconverting enzyme 2 (ACE2) were measured through ELISA and activity assay kits respectively. Angiotensin II (AngII), angiotensin-(1–7) (Ang-1–7), AngII type 1 receptor (AT1R), and Mas receptor were quantified with ELISA and Western blot.Models of acute injury were established successfully and BML-111 protected LPS-induced acute lung injury and LPS/D-GalN-induced acute liver injury. BML-111 repressed the activity of ACE, but increased the activity of ACE2. BML-111 decreased the expression levels of ACE, AngII, and AT1R, meanwhile increased the levels of ACE2, Ang-(1–7), and Mas. Furthermore, BOC-2, an inhibitor of lipoxin receptor, reversed all the effects.BML-111 could protect against acute injury via regulation RAAS." @default.
- W2331273746 created "2016-06-24" @default.
- W2331273746 creator A5037407523 @default.
- W2331273746 date "1986-01-01" @default.
- W2331273746 modified "2023-09-23" @default.
- W2331273746 title "Coastal states, regional powers, superpowers and the Malacca—Singapore straits" @default.
- W2331273746 doi "https://doi.org/10.1016/0260-9827(86)90016-9" @default.
- W2331273746 hasPublicationYear "1986" @default.
- W2331273746 type Work @default.
- W2331273746 sameAs 2331273746 @default.
- W2331273746 citedByCount "0" @default.
- W2331273746 crossrefType "journal-article" @default.
- W2331273746 hasAuthorship W2331273746A5037407523 @default.
- W2331273746 hasConcept C104317684 @default.
- W2331273746 hasConcept C126322002 @default.
- W2331273746 hasConcept C134018914 @default.
- W2331273746 hasConcept C170493617 @default.
- W2331273746 hasConcept C185592680 @default.
- W2331273746 hasConcept C198710026 @default.
- W2331273746 hasConcept C203565725 @default.
- W2331273746 hasConcept C27016395 @default.
- W2331273746 hasConcept C2775946041 @default.
- W2331273746 hasConcept C2776415932 @default.
- W2331273746 hasConcept C2776914184 @default.
- W2331273746 hasConcept C2778938600 @default.
- W2331273746 hasConcept C2779134260 @default.
- W2331273746 hasConcept C2780415110 @default.
- W2331273746 hasConcept C2908929049 @default.
- W2331273746 hasConcept C3008058167 @default.
- W2331273746 hasConcept C524204448 @default.
- W2331273746 hasConcept C55493867 @default.
- W2331273746 hasConcept C71924100 @default.
- W2331273746 hasConcept C84393581 @default.
- W2331273746 hasConcept C98274493 @default.
- W2331273746 hasConceptScore W2331273746C104317684 @default.
- W2331273746 hasConceptScore W2331273746C126322002 @default.
- W2331273746 hasConceptScore W2331273746C134018914 @default.
- W2331273746 hasConceptScore W2331273746C170493617 @default.
- W2331273746 hasConceptScore W2331273746C185592680 @default.
- W2331273746 hasConceptScore W2331273746C198710026 @default.
- W2331273746 hasConceptScore W2331273746C203565725 @default.
- W2331273746 hasConceptScore W2331273746C27016395 @default.
- W2331273746 hasConceptScore W2331273746C2775946041 @default.
- W2331273746 hasConceptScore W2331273746C2776415932 @default.
- W2331273746 hasConceptScore W2331273746C2776914184 @default.
- W2331273746 hasConceptScore W2331273746C2778938600 @default.
- W2331273746 hasConceptScore W2331273746C2779134260 @default.
- W2331273746 hasConceptScore W2331273746C2780415110 @default.
- W2331273746 hasConceptScore W2331273746C2908929049 @default.
- W2331273746 hasConceptScore W2331273746C3008058167 @default.
- W2331273746 hasConceptScore W2331273746C524204448 @default.
- W2331273746 hasConceptScore W2331273746C55493867 @default.
- W2331273746 hasConceptScore W2331273746C71924100 @default.
- W2331273746 hasConceptScore W2331273746C84393581 @default.
- W2331273746 hasConceptScore W2331273746C98274493 @default.
- W2331273746 hasIssue "1" @default.
- W2331273746 hasLocation W23312737461 @default.
- W2331273746 hasOpenAccess W2331273746 @default.
- W2331273746 hasPrimaryLocation W23312737461 @default.
- W2331273746 hasRelatedWork W1520957183 @default.
- W2331273746 hasRelatedWork W2019009753 @default.
- W2331273746 hasRelatedWork W2112443030 @default.
- W2331273746 hasRelatedWork W2126797993 @default.
- W2331273746 hasRelatedWork W2132612653 @default.
- W2331273746 hasRelatedWork W2149410839 @default.
- W2331273746 hasRelatedWork W2162471541 @default.
- W2331273746 hasRelatedWork W2190649397 @default.
- W2331273746 hasRelatedWork W2591366330 @default.
- W2331273746 hasRelatedWork W2899864694 @default.
- W2331273746 hasVolume "5" @default.
- W2331273746 isParatext "false" @default.
- W2331273746 isRetracted "false" @default.
- W2331273746 magId "2331273746" @default.
- W2331273746 workType "article" @default.