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• W2331295151 abstract "Abstract The antioxidant activity of the different polyphenolic extracts prepared from Tunisian azarole, Crataegus azarolus and Crataegus monogyna ( Rosaceae family) leaves, fruit peel, pulp and syrup was evaluated using cholesterol, liposome and rat liver-homogenate oxidation assays and cytotoxic activity in differentiated Caco-2, undifferentiated Caco-2, and B16F10 melanoma cells. Protective effects were observed against thermal-cholesterol degradation at 140 °C for 1 h, which depended on the concentration and the type of the extract. Moreover, the pre-treatment with the phenolic extracts preserved liposomes and rat liver-homogenate from oxidative induced damage by Cu 2+ and Fe 2+ at 37 °C for 24 h and 2 h, respectively. Azarole phenolics inhibited the oxidation of polyunsaturated fatty acids (PUFA) and limited the production of oxidized compounds. Furthermore, within tested concentrations (0.24-4.8 mg/mL), all extracts did not show any toxic effect on differentiated Caco-2 cells; while, they were found cytotoxic to cancer Caco-2 cells, except, extracts of pulp and syrup of C. monogyna . Using B16F10 melanoma cell model, only azarole pulp and syrup extracts were found toxic and induced the production of melanin in a dose-dependent manner." @default.
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• W2331295151 date "2016-08-01" @default.
• W2331295151 modified "2023-09-23" @default.
• W2331295151 title "Protective effects of azarole polyphenolic extracts against oxidative damage using in vitro biomolecular and cellular models" @default.
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• W2331295151 doi "https://doi.org/10.1016/j.indcrop.2016.04.003" @default.
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