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• W2331320804 abstract "Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1–3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1–3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-α, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner." @default.
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• W2331320804 date "2014-12-02" @default.
• W2331320804 modified "2023-09-24" @default.
• W2331320804 title "Monanchosterols A and B, Bioactive Bicyclo[4.3.1]steroids from a Korean Sponge <i>Monanchora</i> sp." @default.
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• W2331320804 doi "https://doi.org/10.1021/np500760v" @default.
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