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• W2331445860 abstract "Event Abstract Back to Event Structural insight on the recognition of surface-bound opsonins by the integrin αI-domain of complement receptor 3 Goran Bajic1, Laure Yatime1, Thomas Vorup-Jensen2 and Gregers R. Andersen1* 1 Aarhus University, Department of Molecular Biology and Genetics, Denmark 2 Aarhus University, Department of Biomedicine, Denmark Complement is the first line of defense against invading pathogens and bridges the innate and the adaptive immunity. Complement activation leads to proteolysis of the central complement component, C3, yielding an anaphylatoxin C3a and an opsonin C3b. The latter becomes covalently bound to the target surface via its reactive thioester. C3b is further processed into iC3b and C3dg by factors I and H and finally to C3d by other plasma proteases. These fragments are ligands for complement receptors expressed on immune cells. Amongst these, integrin receptors CR3 (CD11b/CD18, αMβ2, Mac-1) and CR4 (CD11c/CD18, αXβ2) are essential for the recognition and phagocytosis of immune complexes. Until now, a systematic comparison of the binding selectivity amongst C3 fragments for these receptors has been lacking. Furthermore the CR3 binding-site on the C3 molecule has not been identified so far. By using cell-adhesion and SPR assays, we have identified the minimal binding domain of C3 for CR3. Surprisingly, these results reveal a difference in selectivity towards C3 fragments for CR3 and CR4, since CR3 preferentially binds to C3d. Furthermore, we report the crystal structure of the CR3 I-domain in complex with C3d at 2.8 Å resolution. This structure provides the first atomic model for CR3 binding to iC3b, C3dg or C3d and explains the lack of binding to C3b. In addition, our structure suggests a simultaneous binding of CR3 and another receptor, CR2, to C3 fragments, which might be important for trafficking of opsonized antigen in lymph nodes between B-cells and follicular dendritic cells. Keywords: Immunity, innate immunity, Innate immune system, Complement System Proteins, Complement C3, Integrins, Structure, Structural Biology, X-ray crystallography Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Innate immunity Citation: Bajic G, Yatime L, Vorup-Jensen T and Andersen GR (2013). Structural insight on the recognition of surface-bound opsonins by the integrin αI-domain of complement receptor 3. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.01020 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Prof. Gregers R Andersen, Aarhus University, Department of Molecular Biology and Genetics, Aarhus, 8000, Denmark, gra@mbg.au.dk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Goran Bajic Laure Yatime Thomas Vorup-Jensen Gregers R Andersen Google Goran Bajic Laure Yatime Thomas Vorup-Jensen Gregers R Andersen Google Scholar Goran Bajic Laure Yatime Thomas Vorup-Jensen Gregers R Andersen PubMed Goran Bajic Laure Yatime Thomas Vorup-Jensen Gregers R Andersen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2331445860 title "Structural insight on the recognition of surface-bound opsonins by the integrin aI-domain of complement receptor 3" @default.
• W2331445860 doi "https://doi.org/10.3389/conf.fimmu.2013.02.01020" @default.
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