Matches in SemOpenAlex for { <https://semopenalex.org/work/W2331488822> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2331488822 endingPage "H732" @default.
- W2331488822 startingPage "H725" @default.
- W2331488822 abstract "Smooth muscle cells (SMC) from prosthetic vascular grafts constitutively secrete higher levels of platelet-derived growth factor-AA (PDGF-AA) than aortic SMC. Lipid oxidation products accumulate in grafts and may stimulate PDGF production. The effect of oxidized low-density lipoprotein (oxLDL) on PDGF-AA secretion by aortic and graft SMC was compared. SMC isolated from canine thoracic aorta or Dacron thoracoabdominal grafts (n = 10) were incubated with native LDL or oxLDL (0-400 microg/ml) for 72 h. PDGF-AA in the conditioned medium was measured with enzyme-linked immunosorbent assay. OxLDL increased PDGF-AA production by graft SMC from 78 +/- 2 to 256 +/- 16 pg PDGF/microg DNA and aortic SMC from 21 +/- 1 to 40 +/- 2 pg PDGF/microg DNA. Native LDL had no effect. N-acetylcysteine inhibited oxLDL-induced PDGF increase. Both superoxide and H(2)O(2) stimulated PDGF secretion by graft SMC had little effect on aortic SMC. Our results suggest that PDGF production by graft (synthetic) SMC is more sensitive to stimulation by oxidative stress than aortic (contractile) SMC. Lipid oxidation products that accumulate in prosthetic vascular grafts can cause an oxidative stress, which stimulates PDGF production by graft SMC. PDGF can induce migration of aortic SMC onto the graft, contributing to the development of intimal hyperplasia." @default.
- W2331488822 created "2016-06-24" @default.
- W2331488822 creator A5031081140 @default.
- W2331488822 creator A5044527267 @default.
- W2331488822 creator A5049307963 @default.
- W2331488822 creator A5080776899 @default.
- W2331488822 date "2002-08-01" @default.
- W2331488822 modified "2023-09-23" @default.
- W2331488822 title "Differential PDGF secretion by graft and aortic SMC in response to oxidized LDL" @default.
- W2331488822 cites W1966489575 @default.
- W2331488822 cites W1968529156 @default.
- W2331488822 cites W1971627032 @default.
- W2331488822 cites W1977779461 @default.
- W2331488822 cites W1978607604 @default.
- W2331488822 cites W1993176770 @default.
- W2331488822 cites W1993255165 @default.
- W2331488822 cites W1995285367 @default.
- W2331488822 cites W2007303151 @default.
- W2331488822 cites W2008120093 @default.
- W2331488822 cites W2009560671 @default.
- W2331488822 cites W2014751729 @default.
- W2331488822 cites W2015219342 @default.
- W2331488822 cites W2020770717 @default.
- W2331488822 cites W2051953633 @default.
- W2331488822 cites W2053837324 @default.
- W2331488822 cites W2059618963 @default.
- W2331488822 cites W2070951814 @default.
- W2331488822 cites W2078713011 @default.
- W2331488822 cites W2131526700 @default.
- W2331488822 cites W2149897099 @default.
- W2331488822 cites W2150231536 @default.
- W2331488822 cites W2151631303 @default.
- W2331488822 cites W2166741288 @default.
- W2331488822 cites W2169208391 @default.
- W2331488822 cites W2303418338 @default.
- W2331488822 cites W2341350186 @default.
- W2331488822 cites W2397981299 @default.
- W2331488822 doi "https://doi.org/10.1152/ajpheart.00060.2002" @default.
- W2331488822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12124221" @default.
- W2331488822 hasPublicationYear "2002" @default.
- W2331488822 type Work @default.
- W2331488822 sameAs 2331488822 @default.
- W2331488822 citedByCount "15" @default.
- W2331488822 countsByYear W23314888222014 @default.
- W2331488822 countsByYear W23314888222016 @default.
- W2331488822 countsByYear W23314888222017 @default.
- W2331488822 countsByYear W23314888222022 @default.
- W2331488822 crossrefType "journal-article" @default.
- W2331488822 hasAuthorship W2331488822A5031081140 @default.
- W2331488822 hasAuthorship W2331488822A5044527267 @default.
- W2331488822 hasAuthorship W2331488822A5049307963 @default.
- W2331488822 hasAuthorship W2331488822A5080776899 @default.
- W2331488822 hasConcept C134018914 @default.
- W2331488822 hasConcept C170493617 @default.
- W2331488822 hasConcept C180361614 @default.
- W2331488822 hasConcept C185592680 @default.
- W2331488822 hasConcept C2775960820 @default.
- W2331488822 hasConcept C2776151105 @default.
- W2331488822 hasConcept C2781294074 @default.
- W2331488822 hasConcept C49039625 @default.
- W2331488822 hasConcept C55493867 @default.
- W2331488822 hasConcept C86803240 @default.
- W2331488822 hasConceptScore W2331488822C134018914 @default.
- W2331488822 hasConceptScore W2331488822C170493617 @default.
- W2331488822 hasConceptScore W2331488822C180361614 @default.
- W2331488822 hasConceptScore W2331488822C185592680 @default.
- W2331488822 hasConceptScore W2331488822C2775960820 @default.
- W2331488822 hasConceptScore W2331488822C2776151105 @default.
- W2331488822 hasConceptScore W2331488822C2781294074 @default.
- W2331488822 hasConceptScore W2331488822C49039625 @default.
- W2331488822 hasConceptScore W2331488822C55493867 @default.
- W2331488822 hasConceptScore W2331488822C86803240 @default.
- W2331488822 hasIssue "2" @default.
- W2331488822 hasLocation W23314888221 @default.
- W2331488822 hasLocation W23314888222 @default.
- W2331488822 hasOpenAccess W2331488822 @default.
- W2331488822 hasPrimaryLocation W23314888221 @default.
- W2331488822 hasRelatedWork W2050268899 @default.
- W2331488822 hasRelatedWork W2065434950 @default.
- W2331488822 hasRelatedWork W2078751457 @default.
- W2331488822 hasRelatedWork W2085463220 @default.
- W2331488822 hasRelatedWork W2087890016 @default.
- W2331488822 hasRelatedWork W2094249300 @default.
- W2331488822 hasRelatedWork W2173917538 @default.
- W2331488822 hasRelatedWork W2431952740 @default.
- W2331488822 hasRelatedWork W272577899 @default.
- W2331488822 hasRelatedWork W952563013 @default.
- W2331488822 hasVolume "283" @default.
- W2331488822 isParatext "false" @default.
- W2331488822 isRetracted "false" @default.
- W2331488822 magId "2331488822" @default.
- W2331488822 workType "article" @default.