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• W2331494906 abstract "Event Abstract Back to Event Cellular mechanisms underlying stress-induced coma in the CNS of the locust (Locusta migratoria) Kristin E. Spong1*, Genevieve Rochon-Terry1 and R. Meldrum Robertson1 1 Queen's University, Department of Biology, Canada Locusts enter a reversible coma in response to severe metabolic stress that is associated with abrupt surges in extracellular potassium concentration ([K+] o) within the CNS. Interestingly this K+ disturbance that is observed to propagate through locust neural tissue closely resembles cortical spreading depression (CSD) in mammals which has been associated with pathologies such as stroke, seizures and migraine. We believe that SD-like events in the locust are triggered by a positive feedback cycle initiated when processes of [K+]o accumulation overwhelm the ability to clear [K+]o. Through pharmacological manipulation we planned to elucidate the involvement of glia in locust SD. We monitored SD-like events using K+ sensitive microelectrodes while pharmacologically targeting glial mechanisms of K+ homeostasis. We show that inhibition of glial spatial buffering alone can induce repetitive SD and that disruption of the perineurium (specialized glial cells forming the insects’ blood brain barrier) can increase the severity of stress-induced SD-like events as well as increase the rate of SD propagation. We propose that glial cells play a key role in the generation and recovery from locust SD, and we are now using pharmacological approaches to alter the rate of SD propagation. Acknowledgements NSERC Keywords: glia, Ionic homeostasis, Locust, Metabolic Stress, Spreading depression Conference: Tenth International Congress of Neuroethology, College Park. Maryland USA, United States, 5 Aug - 10 Aug, 2012. Presentation Type: Poster (but consider for student poster award) Topic: Cellular Properties Citation: Spong KE, Rochon-Terry G and Robertson R (2012). Cellular mechanisms underlying stress-induced coma in the CNS of the locust (Locusta migratoria). Conference Abstract: Tenth International Congress of Neuroethology. doi: 10.3389/conf.fnbeh.2012.27.00341 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Apr 2012; Published Online: 07 Jul 2012. * Correspondence: Miss. Kristin E Spong, Queen's University, Department of Biology, Kingston, ON, Canada, 9ks26@queensu.ca Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kristin E Spong Genevieve Rochon-Terry R. Meldrum Robertson Google Kristin E Spong Genevieve Rochon-Terry R. Meldrum Robertson Google Scholar Kristin E Spong Genevieve Rochon-Terry R. Meldrum Robertson PubMed Kristin E Spong Genevieve Rochon-Terry R. Meldrum Robertson Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2331494906 title "Cellular mechanisms underlying stress-induced coma in the CNS of the locust (Locusta migratoria)" @default.
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