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- W2331549720 abstract "Growing evidence suggests that aberration of the DNA repair pathway significantly contributes to tumorigenesis. Single-nucleotide polymorphisms in DNA repair-related genes such as WRN have been implicated in cancer risk. However, the results of published studies remain inconclusive. Therefore, we performed a meta-analysis of all available and relevant published studies to clarify the role of this polymorphism in cancer. We performed a computerized search of PubMed for publications on WRN Cys1367Arg (T>C) polymorphism and cancer risk and analyzed the genotype data. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Sensitivity analysis, heterogeneity test, cumulative meta-analysis, and bias assessment were performed using STATA software 11.0. No association was found between WRN Cys1367Arg (T>C) polymorphism and cancer risk in all genetic models. When stratified by cancer type, results showed that this polymorphism increased the risk of breast cancer (2CC+CT vs 2TT+CT: perallele OR = 1.14, 95% CI = 1.03-1.26, P trend = .012; CC vs TT: OR = 1.43, 95% CI = 1.04-1.95, P value = .026; CC+CT vs TT: OR = 1.14, 95% CI = 1.02-1.28, P value = .027). In another analysis stratified by ethnicity, WRN Cys1367Arg (T>C) polymorphism was significantly associated with cancer susceptibility in Europeans (2CC+CT vs 2TT+CT: perallele OR = 1.09, 95% CI = 1.00-1.19, P trend = .042; CT vs TT: OR = 1.13, 95% CI = 1.01-1.27, P value = .032; and CC+CT vs TT: OR = 1.13, 95% CI = 1.02-1.26, P value = .025). Our study suggests that WRN Cys1367Arg (T>C) polymorphism is not associated with overall cancer risk, although subgroup analyses suggested an association with breast cancer and overall cancer specifically in European populations." @default.
- W2331549720 created "2016-06-24" @default.
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- W2331549720 date "2014-12-02" @default.
- W2331549720 modified "2023-09-25" @default.
- W2331549720 title "Association Between WRN Cys1367Arg (T>C) and Cancer Risk" @default.
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- W2331549720 doi "https://doi.org/10.1177/1533034614561359" @default.
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