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- W2331640346 abstract "Mutations in isocitrate dehydrogenase 1 (IDH1) characterize most adult low-grade gliomas. Mutant IDH1 catalyzes production of the oncometabolite 2-hydroxyglutarate (2-HG). We recently discovered that the IDH1 mutation also reprograms pyruvate metabolism in a 2-HG-dependent manner, and that reprogramming of pyruvate metabolism is essential for cell proliferation in glioma cells with mutant IDH1." @default.
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- W2331640346 date "2015-08-27" @default.
- W2331640346 modified "2023-09-27" @default.
- W2331640346 title "Metabolic reprogramming of pyruvate dehydrogenase is essential for the proliferation of glioma cells expressing mutant IDH1" @default.
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- W2331640346 doi "https://doi.org/10.1080/23723556.2015.1077922" @default.
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