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- W2331664104 abstract "Objectives: Ex-vivo lung perfusion (EVLP) could potentially reduce pulmonary oedema. In a pig model with induced pulmonary oedema, we evaluated the effect of haemofiltration (HF) during EVLP on lung function, perfusate oncotic pressure and lung weight. Methods: In anaesthetised pigs (n = 14), pulmonary oedema was induced by an inflatable balloon in the left atrium for 2 h, combined with crystalloid infusion (20 ml/kg). The lungs were harvested and kept cold for 2 h. The lungs were randomised to EVLP, with (HF group, n = 7) or without (control group, n = 7) a haemofilter. EVLP was performed with cellular perfusate at a haematocrit of 10–15%. Oncotic pressure, lung performance and weight were measured before and after 180 min of EVLP reconditioning ± HF. Results: After induction of oedema in vivo, PaO2/FiO2 and compliance decreased by 63% and 16%, respectively. PaO2/FiO2 was considerably improved at first evaluation ex-vivo. HF increased oncotic pressure by 43% and decreased lung weight by 15%, with negligible effects on these variables in the control group. Compliance decreased in both groups during reconditioning, although less so in the HF group (P < 0.05). PaO2/FiO2, shunt fraction and oxygen saturation remained unchanged in both groups. Pulmonary flow index decreased in both groups, partially reversed by nitroglycerin. Conclusion: In this lung oedema model, EVLP reconditioning with the hyperoncotic Steen solution did not affect the degree of lung oedema. HF during EVLP increased perfusate oncotic pressure, decreased lung weight with beneficial effects on compliance, but did not improve lung oxygenation capacity." @default.
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- W2331664104 date "2014-09-23" @default.
- W2331664104 modified "2023-10-16" @default.
- W2331664104 title "284 * HAEMOFILTRATION IN EX-VIVO LUNG PERFUSION: A STUDY IN EXPERIMENTALLY-INDUCED PULMONARY OEDEMA" @default.
- W2331664104 doi "https://doi.org/10.1093/icvts/ivu276.284" @default.
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