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- W2331732451 abstract "Intestinal transplantation is the logical alternative to definitive total parenteral nutrition in patients with chronic intestinal failure. It has become a lifesaving procedure for infants, children and adults with intestinal failure who cannot be treated using conventional therapies. In children (two thirds of the recipients), indications include short gut syndrome, primary disorders of intestinal motility, and mucosal diseases. In adults, 60% of the indications for intestinal transplantation are inadaptable short bowel syndrome after subtotal or total resection. Dependency on total parenteral nutrition must not be the sole criterion for intestinal transplantation. Factors that raise consideration of small bowel transplantation (SBTx) or liver–small bowel transplantation (LSBTx) include the development of end stage liver failure, impending loss of venous access, and episode of potentially fatal complications such as sepsis. Patients with irreversible intestinal failure and total parenteral nutrition dependency without consistent liver disease must satisfy rigorous criteria to be considered as candidates for isolated SBTx. Patients with irreversible intestinal failure and end-stage liver disease are undoubtedly candidates for a lifesaving procedure such as combined LSBTx. Patients with severe hepatic fibrosis or cirrhosis are thus usually listed for LSBTx. The appropriate timing for referral for transplantation remains vague. Advanced disease has further consequences because a considerable number of patients may die of progressive liver failure or infection before suitable organs can become available. Candidates for intestinal transplantation should be assessed early and should undergo transplantation." @default.
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- W2331732451 title "Indications and strategies for intestinal transplantation" @default.
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- W2331732451 doi "https://doi.org/10.1097/00075200-199912000-00012" @default.
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