Matches in SemOpenAlex for { <https://semopenalex.org/work/W2331796998> ?p ?o ?g. }
- W2331796998 endingPage "R1243" @default.
- W2331796998 startingPage "R1226" @default.
- W2331796998 abstract "Intrauterine growth restriction induced by placental restriction (PR) in sheep leads to chronic hypoxemia and reduced surfactant maturation. The underlying molecular mechanism involves altered regulation of hypoxia signaling by increased prolyl hydroxylase domain (PHD) expression. Here, we evaluated the effect of intratracheal administration of the PHD inhibitor dimethyloxalylglycine (DMOG) on functional, molecular, and structural determinants of lung maturation in the control and PR sheep fetus. There was no effect of DMOG on fetal blood pressure or fetal breathing movements. DMOG reduced lung expression of genes regulating hypoxia signaling ( HIF-3α, ACE1), antioxidant defense ( CAT), lung liquid reabsorption ( SCNN1-A, ATP1-A1, AQP-1, AQP-5), and surfactant maturation ( SFTP-A, SFTP-B, SFTP-C, PCYT1A, LPCAT, ABCA3, LAMP3) in control fetuses. There were very few effects of DMOG on gene expression in the PR fetal lung (reduced lung expression of angiogenic factor ADM, water channel AQP-5, and increased expression of glucose transporter SLC2A1). DMOG administration in controls reduced total lung lavage phosphatidylcholine to the same degree as in PR fetuses. These changes appear to be regulated at the molecular level as there was no effect of DMOG on the percent tissue, air space, or numerical density of SFTP-B positive cells in the control and PR lung. Hence, DMOG administration mimics the effects of PR in reducing surfactant maturation in the lung of control fetuses. The limited responsiveness of the PR fetal lung suggests a potential biochemical limit or reduced plasticity to respond to changes in regulation of hypoxia signaling following exposure to chronic hypoxemia in utero." @default.
- W2331796998 created "2016-06-24" @default.
- W2331796998 creator A5006855131 @default.
- W2331796998 creator A5042366730 @default.
- W2331796998 creator A5047956479 @default.
- W2331796998 date "2016-06-01" @default.
- W2331796998 modified "2023-09-24" @default.
- W2331796998 title "Regulation of lung maturation by prolyl hydroxylase domain inhibition in the lung of the normally grown and placentally restricted fetus in late gestation" @default.
- W2331796998 cites W1577577364 @default.
- W2331796998 cites W1652213260 @default.
- W2331796998 cites W1832165446 @default.
- W2331796998 cites W1842750594 @default.
- W2331796998 cites W1854573849 @default.
- W2331796998 cites W1965667290 @default.
- W2331796998 cites W1967145102 @default.
- W2331796998 cites W1968169835 @default.
- W2331796998 cites W1972782503 @default.
- W2331796998 cites W1973033888 @default.
- W2331796998 cites W1974766166 @default.
- W2331796998 cites W1975511655 @default.
- W2331796998 cites W1986673001 @default.
- W2331796998 cites W1991020045 @default.
- W2331796998 cites W1991114189 @default.
- W2331796998 cites W1995110990 @default.
- W2331796998 cites W2005868568 @default.
- W2331796998 cites W2007243697 @default.
- W2331796998 cites W2008137479 @default.
- W2331796998 cites W2011076742 @default.
- W2331796998 cites W2013085398 @default.
- W2331796998 cites W2016160962 @default.
- W2331796998 cites W2016168978 @default.
- W2331796998 cites W2021656373 @default.
- W2331796998 cites W2025911583 @default.
- W2331796998 cites W2033433389 @default.
- W2331796998 cites W2036649134 @default.
- W2331796998 cites W2037632368 @default.
- W2331796998 cites W2040474895 @default.
- W2331796998 cites W2041855656 @default.
- W2331796998 cites W2042216712 @default.
- W2331796998 cites W2044958187 @default.
- W2331796998 cites W2052092988 @default.
- W2331796998 cites W2054055548 @default.
- W2331796998 cites W2054086195 @default.
- W2331796998 cites W2064239949 @default.
- W2331796998 cites W2065496862 @default.
- W2331796998 cites W2067389552 @default.
- W2331796998 cites W2068312357 @default.
- W2331796998 cites W2072562682 @default.
- W2331796998 cites W2085128107 @default.
- W2331796998 cites W2090476786 @default.
- W2331796998 cites W2093950834 @default.
- W2331796998 cites W2095234730 @default.
- W2331796998 cites W2096040409 @default.
- W2331796998 cites W2097321304 @default.
- W2331796998 cites W2102487206 @default.
- W2331796998 cites W2104135702 @default.
- W2331796998 cites W2106339836 @default.
- W2331796998 cites W2114787081 @default.
- W2331796998 cites W2116106133 @default.
- W2331796998 cites W2130089533 @default.
- W2331796998 cites W2134312287 @default.
- W2331796998 cites W2134392873 @default.
- W2331796998 cites W2138581811 @default.
- W2331796998 cites W2142552813 @default.
- W2331796998 cites W2144625075 @default.
- W2331796998 cites W2152017985 @default.
- W2331796998 cites W2153342358 @default.
- W2331796998 cites W2153545057 @default.
- W2331796998 cites W2154327042 @default.
- W2331796998 cites W2156823180 @default.
- W2331796998 cites W2168420558 @default.
- W2331796998 cites W2168736084 @default.
- W2331796998 cites W2170559724 @default.
- W2331796998 cites W2181906368 @default.
- W2331796998 cites W2216225615 @default.
- W2331796998 cites W2225263353 @default.
- W2331796998 cites W2265303879 @default.
- W2331796998 cites W2402327300 @default.
- W2331796998 cites W2979089137 @default.
- W2331796998 cites W4238010870 @default.
- W2331796998 doi "https://doi.org/10.1152/ajpregu.00469.2015" @default.
- W2331796998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26936783" @default.
- W2331796998 hasPublicationYear "2016" @default.
- W2331796998 type Work @default.
- W2331796998 sameAs 2331796998 @default.
- W2331796998 citedByCount "15" @default.
- W2331796998 countsByYear W23317969982017 @default.
- W2331796998 countsByYear W23317969982018 @default.
- W2331796998 countsByYear W23317969982019 @default.
- W2331796998 countsByYear W23317969982020 @default.
- W2331796998 countsByYear W23317969982021 @default.
- W2331796998 countsByYear W23317969982022 @default.
- W2331796998 crossrefType "journal-article" @default.
- W2331796998 hasAuthorship W2331796998A5006855131 @default.
- W2331796998 hasAuthorship W2331796998A5042366730 @default.
- W2331796998 hasAuthorship W2331796998A5047956479 @default.
- W2331796998 hasBestOaLocation W23317969981 @default.
- W2331796998 hasConcept C104317684 @default.