Matches in SemOpenAlex for { <https://semopenalex.org/work/W2331847365> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2331847365 abstract "Over the past, progress has always been achieved in therapy of various human diseases with the introduction of novel methodologies from basic to clinical research. Recent advances in techniques, especially DNA sequencing and methylation analyses, faster miniaturized proteomics and live cellular stainings, are opening a new era in cancer research. Perhaps the difference this time can be envisaged as the beginning of the long-sought individualization of forthcoming cancer therapies. Cancer has complex genetic susceptibility that is wider than previously thought. Apart from genes encoding six functional capabilities of cancer - independent growth, avoidance of apoptosis, immortalization, multi-drug resistance, neovascularization, and invasiveness - predisposition includes four more factors that promote genome instability, inflammation, deregulation of metabolism as well as evasion of destruction by the immune system. The underlying genetic events, i.e. base-pair DNA mutations, are not the sole factors in cancer development. Additional novel controls of gene expression have been found in the epigenetic machinery, which has been increasingly important in assessing cancer risk in recent years. The predisposing factors, including their regulatory elements, are bona fide potential new targets in prospective cancer pharmacotherapy." @default.
- W2331847365 created "2016-06-24" @default.
- W2331847365 creator A5033232421 @default.
- W2331847365 date "2014-10-22" @default.
- W2331847365 modified "2023-10-17" @default.
- W2331847365 title "Pharmaco-Therapeutic Challenges in Cancer Biology with Focus on the Immune- System Related Risk Factors" @default.
- W2331847365 doi "https://doi.org/10.2174/1381612820666140826154147" @default.
- W2331847365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25341937" @default.
- W2331847365 hasPublicationYear "2014" @default.
- W2331847365 type Work @default.
- W2331847365 sameAs 2331847365 @default.
- W2331847365 citedByCount "2" @default.
- W2331847365 countsByYear W23318473652016 @default.
- W2331847365 countsByYear W23318473652019 @default.
- W2331847365 crossrefType "journal-article" @default.
- W2331847365 hasAuthorship W2331847365A5033232421 @default.
- W2331847365 hasConcept C104317684 @default.
- W2331847365 hasConcept C121608353 @default.
- W2331847365 hasConcept C143425029 @default.
- W2331847365 hasConcept C145059251 @default.
- W2331847365 hasConcept C150194340 @default.
- W2331847365 hasConcept C178169997 @default.
- W2331847365 hasConcept C190727270 @default.
- W2331847365 hasConcept C2780035454 @default.
- W2331847365 hasConcept C2780234812 @default.
- W2331847365 hasConcept C41091548 @default.
- W2331847365 hasConcept C54355233 @default.
- W2331847365 hasConcept C552990157 @default.
- W2331847365 hasConcept C60644358 @default.
- W2331847365 hasConcept C64903051 @default.
- W2331847365 hasConcept C67636389 @default.
- W2331847365 hasConcept C70721500 @default.
- W2331847365 hasConcept C86803240 @default.
- W2331847365 hasConcept C8891405 @default.
- W2331847365 hasConcept C98274493 @default.
- W2331847365 hasConceptScore W2331847365C104317684 @default.
- W2331847365 hasConceptScore W2331847365C121608353 @default.
- W2331847365 hasConceptScore W2331847365C143425029 @default.
- W2331847365 hasConceptScore W2331847365C145059251 @default.
- W2331847365 hasConceptScore W2331847365C150194340 @default.
- W2331847365 hasConceptScore W2331847365C178169997 @default.
- W2331847365 hasConceptScore W2331847365C190727270 @default.
- W2331847365 hasConceptScore W2331847365C2780035454 @default.
- W2331847365 hasConceptScore W2331847365C2780234812 @default.
- W2331847365 hasConceptScore W2331847365C41091548 @default.
- W2331847365 hasConceptScore W2331847365C54355233 @default.
- W2331847365 hasConceptScore W2331847365C552990157 @default.
- W2331847365 hasConceptScore W2331847365C60644358 @default.
- W2331847365 hasConceptScore W2331847365C64903051 @default.
- W2331847365 hasConceptScore W2331847365C67636389 @default.
- W2331847365 hasConceptScore W2331847365C70721500 @default.
- W2331847365 hasConceptScore W2331847365C86803240 @default.
- W2331847365 hasConceptScore W2331847365C8891405 @default.
- W2331847365 hasConceptScore W2331847365C98274493 @default.
- W2331847365 hasLocation W23318473651 @default.
- W2331847365 hasLocation W23318473652 @default.
- W2331847365 hasOpenAccess W2331847365 @default.
- W2331847365 hasPrimaryLocation W23318473651 @default.
- W2331847365 hasRelatedWork W1129553077 @default.
- W2331847365 hasRelatedWork W1534851621 @default.
- W2331847365 hasRelatedWork W1543944384 @default.
- W2331847365 hasRelatedWork W1562714888 @default.
- W2331847365 hasRelatedWork W1979463820 @default.
- W2331847365 hasRelatedWork W1988379368 @default.
- W2331847365 hasRelatedWork W2049607663 @default.
- W2331847365 hasRelatedWork W2077819799 @default.
- W2331847365 hasRelatedWork W2079829211 @default.
- W2331847365 hasRelatedWork W2081905503 @default.
- W2331847365 hasRelatedWork W2484231696 @default.
- W2331847365 hasRelatedWork W2735767394 @default.
- W2331847365 hasRelatedWork W2767142469 @default.
- W2331847365 hasRelatedWork W2773829359 @default.
- W2331847365 hasRelatedWork W2903817533 @default.
- W2331847365 hasRelatedWork W2937107212 @default.
- W2331847365 hasRelatedWork W2969005730 @default.
- W2331847365 hasRelatedWork W4225531978 @default.
- W2331847365 hasRelatedWork W61230199 @default.
- W2331847365 hasRelatedWork W78529160 @default.
- W2331847365 isParatext "false" @default.
- W2331847365 isRetracted "false" @default.
- W2331847365 magId "2331847365" @default.
- W2331847365 workType "article" @default.