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• W2331874435 abstract "Photodamage to the mitochondria of murine leukemia P388 cells resulted in immediate loss of the mitochondrial membrane potential together with the release of cytochrome c into the cytosol. This was followed by a rapid activation of caspase 3-like proteases, as indicated by a marked rise in DEVDase activity. There was no significant effect on WEHDase or VEIDase activities, suggesting that only the late-stage caspases had been effected. The apoptotic response to mitochondrial photodamage was abolished by the broad-spectrum caspase inhibitor zVAD-fmk, but this did not prevent loss of viability after mitochondrial photodamage. These studies indicate that the release of cytochrome c from photodamaged mitochondria is sufficient to directly initiate a caspase-dependent apoptotic response." @default.
• W2331874435 created "2016-06-24" @default.
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• W2331874435 date "1999-01-01" @default.
• W2331874435 modified "2023-10-07" @default.
• W2331874435 title "Photodynamic therapy: A mitochondrial inducer of apoptosis" @default.
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• W2331874435 doi "https://doi.org/10.1038/sj.cdd.4400446" @default.
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