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• W2331878056 abstract "Jiang, Chun and Gabriel G. Haddad. Modulation of K + channels by intracellular ATP in human neocortical neurons. J. Neurophysiol. 77: 93–102, 1997. ATP-modulated K + channels play an important role in regulating membrane excitability during metabolic stress. To characterize such K + channels from the human brain, single channel currents were studied in excised inside-out patches from freshly dissociated human neocortical neurons. Three currents that were sensitive to physiological concentrations of ATP and selectively permeable to K + were identified. One of these currents had a unitary conductance of ∼47 pS and showed a strong inward rectification with symmetric K + concentrations across the membrane. This K + current was inhibited by ATP in a concentration-dependent manner with an IC 50 (half-inhibition of channel activity) of ∼130 μM. Channel activity also was suppressed by ADP, nonhydrolyzable ATP analogue AMP-PNP, and sulfonylurea receptor/channel blocker glibenclamide. The second K + current had a unitary conductance of ∼200 pS and showed a weak inward rectification. Similarly, this current was inhibited by ATP (IC 50 = 350 μM), AMP-PNP, and glibenclamide. Unlike the small-conductance ATP-inhibitable K + channel (S-K ATP ), activation of this large-conductance K + channel (L-K ATP ) required the presence of micromolar concentration of Ca 2+ in the internal solution, but charybdotoxin did not inhibit this channel. The third K + current was also Ca 2+ dependent and had a large conductance (∼280 pS). It was inhibited by external charybdotoxin, iberiotoxin, and tetraethylammonium. In contrast to the other two K ATP channels, ATP enhanced channel open-state probability and unitary conductance, and glibenclamide at concentration of 10–20 μM had no inhibitory effect on this current. K + channels that have single-channel and pharmacological properties similar to these three human ATP-modulated K + channels also were observed in experiments on rat neocortical neurons. These results therefore indicate that K ATP channels are expressed in human neocortical neurons, and two distinct K ATP channels (S-K ATP and L-K ATP ) exist in the human and rat neurons. The observation that ATP at different concentrations modulates different K + channels suggests that metabolic rate may be continuously sensed in neurons with resulting alterations in neuronal membrane excitability." @default.
• W2331878056 created "2016-06-24" @default.
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• W2331878056 date "1997-01-01" @default.
• W2331878056 modified "2023-09-27" @default.
• W2331878056 title "Modulation of K⁺Channels by Intracellular ATP in Human Neocortical Neurons" @default.
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• W2331878056 doi "https://doi.org/10.1152/jn.1997.77.1.93" @default.
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