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- W2331916673 abstract "Background: Combined Pulmonary Fibrosis and Emphysema (CPFE) is a new category of interatital lung diseases named in 2005 by Cottin et al. The syndrome is strongly relateg with smoking history and frequently combined by lung cancer. However, the clinical course of those patients has not comprehensively described. Method: A review of all patients of lung cancer treated by chemotherapy or chemo-radiotherapy from January 2009 to December 2012 was conducted. Diagnosis of CPFE was based on CT finding, and patients with connective tissue disease and with a diagnosis of other interstitial lung disease was excluded. Result: CPFE were identified in 48 patients. There were 12 CPFE patients in 104 adenocarcinoma patients, 13 in 59 squamous cell carcinoma, 5 in 30 non-small cell carcinoma, and 18 in 119 small cell carcinoma. Nine patients underwent chemo-radiotherapy, and radiation pneumonitis was observed in 6 patients (G2 = 5, G3 = 1). Chemotherapy was given to 39 patients and drug-induced lung injury occurred in 1 patient. Overall survival was 9.7 months in non-small cell carcinoma patients, and 11.4 months in small cell carcinoma patients. Conclusions: In this study, the incidence rate of treatment-related lung injury was not so high as reported in previous study about chemotherapy for lung cancer patients with interstitial pneumonitis. Since the pathogenesis and the deference between CPFE and other interstitial pneumonitis is still unclear, more investigation about this syndrome is needed and the indication for treatment to combining lung cancer should be considered." @default.
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- W2331916673 date "2013-11-01" @default.
- W2331916673 modified "2023-09-26" @default.
- W2331916673 title "Lung Cancer in Patients with Combined Pulmonary Fibrosis and Emphysema" @default.
- W2331916673 doi "https://doi.org/10.1093/annonc/mdt459.64" @default.
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