FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2331937314> ?p ?o ?g. }

• W2331937314 endingPage "1464" @default.
• W2331937314 startingPage "1457" @default.
• W2331937314 abstract "Testicular germ cell tumours are hypersentive to chemotherapy and cell lines derived from these tumours are chemosensitive in vitro. We have previously shown that these cell lines express undetectable levels of the suppressor of apoptosis Bcl-2 and relatively high levels of the apoptosis inducer Bax (Chresta et al., 1996). To determine whether the absence of Bcl-2 in these cell lines makes them highly susceptible to drug-induced apoptosis, Bcl-2 was expressed ectopically in the 833K testicular germ cell tumour cell line. Stable overexpressing clones were isolated and three clones were studied further. Surprisingly, Bcl-2 overexpressing cells were sensitized to chemotherapy-induced apoptosis compared to the parental and vector control cells. Analysis of potential mechanisms of sensitization revealed there was a reciprocal downregulation of the endogenously expressed Bcl-XL in the Bcl-2 overexpressing clones. Downregulation of Bcl-XL to the same extent using antisense oligonucleotides enhanced etoposide-induced apoptosis by twofold. Our results indicate that Bcl-2 and Bcl-XL have different abilities to protect against chemotherapy-induced apoptosis in testicular germ cell tumours. In contrast to findings in some tumour cell types, Bcl-2 did not act as a gatekeeper to prevent entry of p53 to the nucleus." @default.
• W2331937314 created "2016-06-24" @default.
• W2331937314 creator A5013128561 @default.
• W2331937314 creator A5014472978 @default.
• W2331937314 creator A5017227434 @default.
• W2331937314 creator A5042397037 @default.
• W2331937314 date "1999-02-18" @default.
• W2331937314 modified "2023-10-18" @default.
• W2331937314 title "Bcl-2 overexpression results in reciprocal downregulation of Bcl-XL and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis" @default.
• W2331937314 cites W1621124914 @default.
• W2331937314 cites W1861752925 @default.
• W2331937314 cites W1966539065 @default.
• W2331937314 cites W1967844100 @default.
• W2331937314 cites W1970629830 @default.
• W2331937314 cites W1979995768 @default.
• W2331937314 cites W1991830067 @default.
• W2331937314 cites W1996522179 @default.
• W2331937314 cites W2001880177 @default.
• W2331937314 cites W2020721942 @default.
• W2331937314 cites W2022273331 @default.
• W2331937314 cites W2028625808 @default.
• W2331937314 cites W2031104898 @default.
• W2331937314 cites W2033873142 @default.
• W2331937314 cites W2037758170 @default.
• W2331937314 cites W2049648341 @default.
• W2331937314 cites W2054211883 @default.
• W2331937314 cites W2057713336 @default.
• W2331937314 cites W2058591356 @default.
• W2331937314 cites W2067805812 @default.
• W2331937314 cites W2070862399 @default.
• W2331937314 cites W2077696520 @default.
• W2331937314 cites W2092759765 @default.
• W2331937314 cites W2106540708 @default.
• W2331937314 cites W2130866079 @default.
• W2331937314 cites W2131616553 @default.
• W2331937314 cites W2132479515 @default.
• W2331937314 cites W2134872883 @default.
• W2331937314 cites W2134979684 @default.
• W2331937314 cites W2135753091 @default.
• W2331937314 cites W2144701362 @default.
• W2331937314 cites W2328799185 @default.
• W2331937314 cites W2335497392 @default.
• W2331937314 cites W29766578 @default.
• W2331937314 cites W4243438773 @default.
• W2331937314 cites W43675158 @default.
• W2331937314 cites W53848852 @default.
• W2331937314 doi "https://doi.org/10.1038/sj.onc.1202420" @default.
• W2331937314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10050882" @default.
• W2331937314 hasPublicationYear "1999" @default.
• W2331937314 type Work @default.
• W2331937314 sameAs 2331937314 @default.
• W2331937314 citedByCount "74" @default.
• W2331937314 countsByYear W23319373142012 @default.
• W2331937314 countsByYear W23319373142013 @default.
• W2331937314 countsByYear W23319373142014 @default.
• W2331937314 countsByYear W23319373142016 @default.
• W2331937314 countsByYear W23319373142017 @default.
• W2331937314 crossrefType "journal-article" @default.
• W2331937314 hasAuthorship W2331937314A5013128561 @default.
• W2331937314 hasAuthorship W2331937314A5014472978 @default.
• W2331937314 hasAuthorship W2331937314A5017227434 @default.
• W2331937314 hasAuthorship W2331937314A5042397037 @default.
• W2331937314 hasBestOaLocation W23319373141 @default.
• W2331937314 hasConcept C104317684 @default.
• W2331937314 hasConcept C127561419 @default.
• W2331937314 hasConcept C1491633281 @default.
• W2331937314 hasConcept C153911025 @default.
• W2331937314 hasConcept C190283241 @default.
• W2331937314 hasConcept C2776694085 @default.
• W2331937314 hasConcept C2776789625 @default.
• W2331937314 hasConcept C2778119113 @default.
• W2331937314 hasConcept C2779122487 @default.
• W2331937314 hasConcept C31573885 @default.
• W2331937314 hasConcept C502942594 @default.
• W2331937314 hasConcept C54009773 @default.
• W2331937314 hasConcept C54355233 @default.
• W2331937314 hasConcept C81885089 @default.
• W2331937314 hasConcept C86803240 @default.
• W2331937314 hasConcept C95444343 @default.
• W2331937314 hasConceptScore W2331937314C104317684 @default.
• W2331937314 hasConceptScore W2331937314C127561419 @default.
• W2331937314 hasConceptScore W2331937314C1491633281 @default.
• W2331937314 hasConceptScore W2331937314C153911025 @default.
• W2331937314 hasConceptScore W2331937314C190283241 @default.
• W2331937314 hasConceptScore W2331937314C2776694085 @default.
• W2331937314 hasConceptScore W2331937314C2776789625 @default.
• W2331937314 hasConceptScore W2331937314C2778119113 @default.
• W2331937314 hasConceptScore W2331937314C2779122487 @default.
• W2331937314 hasConceptScore W2331937314C31573885 @default.
• W2331937314 hasConceptScore W2331937314C502942594 @default.
• W2331937314 hasConceptScore W2331937314C54009773 @default.
• W2331937314 hasConceptScore W2331937314C54355233 @default.
• W2331937314 hasConceptScore W2331937314C81885089 @default.
• W2331937314 hasConceptScore W2331937314C86803240 @default.
• W2331937314 hasConceptScore W2331937314C95444343 @default.
• W2331937314 hasIssue "7" @default.
• W2331937314 hasLocation W23319373141 @default.
• W2331937314 hasLocation W23319373142 @default.

• next