FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2331950914> ?p ?o ?g. }

• W2331950914 endingPage "e0150026" @default.
• W2331950914 startingPage "e0150026" @default.
• W2331950914 abstract "Chemotherapeutic insensitivity remains a major obstacle to treating osteosarcoma effectively. Recently, increasing evidence has suggested that microRNAs (miRNAs) are involved in drug resistance. However, the effect of miR-138 on cisplatin chemoresistance in osteosarcoma has not been reported. We used real-time PCR to detect the expression of mature miR-138 in osteosarcoma tissues and cell lines. Cell proliferation, invasion, and migration assays were used to observe changes to the osteosarcoma malignant phenotype. MiR-138 was downregulated in osteosarcoma tissues and cell lines, and miR-138 overexpression negatively regulated osteosarcoma cell proliferation, migration, and invasion. We also verified that EZH2 is a direct target of miR-138. Furthermore, enhancing EZH2 expression reduced the inhibitory effects of miR-138 on osteosarcoma. Proliferation, apoptosis assays and caspase-3 activity assay confirmed that elevated miR-138 expression enhanced osteosarcoma cell chemosensitivity to cisplatin by targeting EZH2. In conclusion, the present study demonstrates that miR-138 acts as a tumor suppressor by enhancing osteosarcoma cell chemosensitivity and supports its potential application for treating osteosarcoma in the future." @default.
• W2331950914 created "2016-06-24" @default.
• W2331950914 creator A5013507121 @default.
• W2331950914 creator A5019485232 @default.
• W2331950914 creator A5036882735 @default.
• W2331950914 creator A5044417450 @default.
• W2331950914 creator A5073319434 @default.
• W2331950914 creator A5086497597 @default.
• W2331950914 date "2016-03-28" @default.
• W2331950914 modified "2023-10-13" @default.
• W2331950914 title "MiR-138 Acts as a Tumor Suppressor by Targeting EZH2 and Enhances Cisplatin-Induced Apoptosis in Osteosarcoma Cells" @default.
• W2331950914 cites W1561249607 @default.
• W2331950914 cites W1652731649 @default.
• W2331950914 cites W1900209405 @default.
• W2331950914 cites W1926460199 @default.
• W2331950914 cites W1979399839 @default.
• W2331950914 cites W1988325237 @default.
• W2331950914 cites W1993275629 @default.
• W2331950914 cites W1994493099 @default.
• W2331950914 cites W1996487270 @default.
• W2331950914 cites W1996543107 @default.
• W2331950914 cites W2005274097 @default.
• W2331950914 cites W2011181841 @default.
• W2331950914 cites W2015132841 @default.
• W2331950914 cites W2026104663 @default.
• W2331950914 cites W2053855502 @default.
• W2331950914 cites W2069747971 @default.
• W2331950914 cites W2083463213 @default.
• W2331950914 cites W2098002569 @default.
• W2331950914 cites W2099033106 @default.
• W2331950914 cites W2107268184 @default.
• W2331950914 cites W2128928017 @default.
• W2331950914 cites W2131112855 @default.
• W2331950914 cites W2137122561 @default.
• W2331950914 cites W2138189882 @default.
• W2331950914 cites W2162227193 @default.
• W2331950914 cites W2162465955 @default.
• W2331950914 cites W2289822130 @default.
• W2331950914 cites W2394954899 @default.
• W2331950914 cites W3146360245 @default.
• W2331950914 cites W327384751 @default.
• W2331950914 cites W637188692 @default.
• W2331950914 cites W829103361 @default.
• W2331950914 doi "https://doi.org/10.1371/journal.pone.0150026" @default.
• W2331950914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4809565" @default.
• W2331950914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27019355" @default.
• W2331950914 hasPublicationYear "2016" @default.
• W2331950914 type Work @default.
• W2331950914 sameAs 2331950914 @default.
• W2331950914 citedByCount "69" @default.
• W2331950914 countsByYear W23319509142016 @default.
• W2331950914 countsByYear W23319509142017 @default.
• W2331950914 countsByYear W23319509142018 @default.
• W2331950914 countsByYear W23319509142019 @default.
• W2331950914 countsByYear W23319509142020 @default.
• W2331950914 countsByYear W23319509142021 @default.
• W2331950914 countsByYear W23319509142022 @default.
• W2331950914 crossrefType "journal-article" @default.
• W2331950914 hasAuthorship W2331950914A5013507121 @default.
• W2331950914 hasAuthorship W2331950914A5019485232 @default.
• W2331950914 hasAuthorship W2331950914A5036882735 @default.
• W2331950914 hasAuthorship W2331950914A5044417450 @default.
• W2331950914 hasAuthorship W2331950914A5073319434 @default.
• W2331950914 hasAuthorship W2331950914A5086497597 @default.
• W2331950914 hasBestOaLocation W23319509141 @default.
• W2331950914 hasConcept C104317684 @default.
• W2331950914 hasConcept C145059251 @default.
• W2331950914 hasConcept C1491633281 @default.
• W2331950914 hasConcept C150194340 @default.
• W2331950914 hasConcept C190283241 @default.
• W2331950914 hasConcept C2776694085 @default.
• W2331950914 hasConcept C2777760704 @default.
• W2331950914 hasConcept C2778239845 @default.
• W2331950914 hasConcept C50171091 @default.
• W2331950914 hasConcept C502942594 @default.
• W2331950914 hasConcept C54355233 @default.
• W2331950914 hasConcept C62112901 @default.
• W2331950914 hasConcept C81885089 @default.
• W2331950914 hasConcept C86803240 @default.
• W2331950914 hasConceptScore W2331950914C104317684 @default.
• W2331950914 hasConceptScore W2331950914C145059251 @default.
• W2331950914 hasConceptScore W2331950914C1491633281 @default.
• W2331950914 hasConceptScore W2331950914C150194340 @default.
• W2331950914 hasConceptScore W2331950914C190283241 @default.
• W2331950914 hasConceptScore W2331950914C2776694085 @default.
• W2331950914 hasConceptScore W2331950914C2777760704 @default.
• W2331950914 hasConceptScore W2331950914C2778239845 @default.
• W2331950914 hasConceptScore W2331950914C50171091 @default.
• W2331950914 hasConceptScore W2331950914C502942594 @default.
• W2331950914 hasConceptScore W2331950914C54355233 @default.
• W2331950914 hasConceptScore W2331950914C62112901 @default.
• W2331950914 hasConceptScore W2331950914C81885089 @default.
• W2331950914 hasConceptScore W2331950914C86803240 @default.
• W2331950914 hasIssue "3" @default.
• W2331950914 hasLocation W23319509141 @default.
• W2331950914 hasLocation W23319509142 @default.
• W2331950914 hasLocation W23319509143 @default.
• W2331950914 hasLocation W23319509144 @default.

• next