Matches in SemOpenAlex for { <https://semopenalex.org/work/W2331967345> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2331967345 endingPage "1370" @default.
- W2331967345 startingPage "1360" @default.
- W2331967345 abstract "Mathematical models of dose controlled reactions based on heat flow data(1, 2) are quite common and well developed; however, such predictions for nondose controlled reactions from heat flow data are difficult, requiring extensive study of the kinetics of multiple chemical transformations as well as physical phenomena such as dissolution and diffusion. Presented here is a new scale-down methodology to directly observe, in the laboratory, a variety of dose controlled and nondose controlled large scale thermal effects. This experiment-based scale-down approach has been derived mathematically from first principles, as well as demonstrated experimentally. This approach limits the heat transfer of the laboratory reactor to the scale equivalent of the intended large scale vessel by dynamic jacket set points based on the ratio of the heat transfer coefficients of lab and plant scale reactors. This allows large scale reaction temperature and other temperature-related effects to be mimicked on small scale while maintaining the time/reaction temperature response profile of the large scale vessel in the laboratory. The result is a method for the direct observation, in the laboratory, of the scale-up effects of changing a wide range of process variables for both dose controlled and non-dose controlled systems. Applications for this methodology could include evaluating the effects of proposed large scale process changes on process safety, product purity, or product physical properties as well as evaluating the effects of failure scenarios." @default.
- W2331967345 created "2016-06-24" @default.
- W2331967345 creator A5047501853 @default.
- W2331967345 creator A5086445072 @default.
- W2331967345 date "2012-07-26" @default.
- W2331967345 modified "2023-10-09" @default.
- W2331967345 title "Heat Transfer Based Scale-Down of Chemical Reactions" @default.
- W2331967345 cites W2079979773 @default.
- W2331967345 cites W2130559585 @default.
- W2331967345 cites W2480090540 @default.
- W2331967345 doi "https://doi.org/10.1021/op300036p" @default.
- W2331967345 hasPublicationYear "2012" @default.
- W2331967345 type Work @default.
- W2331967345 sameAs 2331967345 @default.
- W2331967345 citedByCount "2" @default.
- W2331967345 countsByYear W23319673452018 @default.
- W2331967345 countsByYear W23319673452020 @default.
- W2331967345 crossrefType "journal-article" @default.
- W2331967345 hasAuthorship W2331967345A5047501853 @default.
- W2331967345 hasAuthorship W2331967345A5086445072 @default.
- W2331967345 hasConcept C108213311 @default.
- W2331967345 hasConcept C111919701 @default.
- W2331967345 hasConcept C116915560 @default.
- W2331967345 hasConcept C121332964 @default.
- W2331967345 hasConcept C127413603 @default.
- W2331967345 hasConcept C178790620 @default.
- W2331967345 hasConcept C185592680 @default.
- W2331967345 hasConcept C186060115 @default.
- W2331967345 hasConcept C192562407 @default.
- W2331967345 hasConcept C204530211 @default.
- W2331967345 hasConcept C21880701 @default.
- W2331967345 hasConcept C2777874358 @default.
- W2331967345 hasConcept C2778755073 @default.
- W2331967345 hasConcept C41008148 @default.
- W2331967345 hasConcept C50517652 @default.
- W2331967345 hasConcept C62520636 @default.
- W2331967345 hasConcept C69357855 @default.
- W2331967345 hasConcept C74650414 @default.
- W2331967345 hasConcept C86803240 @default.
- W2331967345 hasConcept C88380143 @default.
- W2331967345 hasConcept C97355855 @default.
- W2331967345 hasConcept C98045186 @default.
- W2331967345 hasConceptScore W2331967345C108213311 @default.
- W2331967345 hasConceptScore W2331967345C111919701 @default.
- W2331967345 hasConceptScore W2331967345C116915560 @default.
- W2331967345 hasConceptScore W2331967345C121332964 @default.
- W2331967345 hasConceptScore W2331967345C127413603 @default.
- W2331967345 hasConceptScore W2331967345C178790620 @default.
- W2331967345 hasConceptScore W2331967345C185592680 @default.
- W2331967345 hasConceptScore W2331967345C186060115 @default.
- W2331967345 hasConceptScore W2331967345C192562407 @default.
- W2331967345 hasConceptScore W2331967345C204530211 @default.
- W2331967345 hasConceptScore W2331967345C21880701 @default.
- W2331967345 hasConceptScore W2331967345C2777874358 @default.
- W2331967345 hasConceptScore W2331967345C2778755073 @default.
- W2331967345 hasConceptScore W2331967345C41008148 @default.
- W2331967345 hasConceptScore W2331967345C50517652 @default.
- W2331967345 hasConceptScore W2331967345C62520636 @default.
- W2331967345 hasConceptScore W2331967345C69357855 @default.
- W2331967345 hasConceptScore W2331967345C74650414 @default.
- W2331967345 hasConceptScore W2331967345C86803240 @default.
- W2331967345 hasConceptScore W2331967345C88380143 @default.
- W2331967345 hasConceptScore W2331967345C97355855 @default.
- W2331967345 hasConceptScore W2331967345C98045186 @default.
- W2331967345 hasIssue "8" @default.
- W2331967345 hasLocation W23319673451 @default.
- W2331967345 hasOpenAccess W2331967345 @default.
- W2331967345 hasPrimaryLocation W23319673451 @default.
- W2331967345 hasRelatedWork W1551793917 @default.
- W2331967345 hasRelatedWork W1557063342 @default.
- W2331967345 hasRelatedWork W2029177633 @default.
- W2331967345 hasRelatedWork W2073116507 @default.
- W2331967345 hasRelatedWork W2148021953 @default.
- W2331967345 hasRelatedWork W2331967345 @default.
- W2331967345 hasRelatedWork W2748952813 @default.
- W2331967345 hasRelatedWork W2899084033 @default.
- W2331967345 hasRelatedWork W2971250989 @default.
- W2331967345 hasRelatedWork W3047863236 @default.
- W2331967345 hasVolume "16" @default.
- W2331967345 isParatext "false" @default.
- W2331967345 isRetracted "false" @default.
- W2331967345 magId "2331967345" @default.
- W2331967345 workType "article" @default.