Matches in SemOpenAlex for { <https://semopenalex.org/work/W2331978103> ?p ?o ?g. }
- W2331978103 endingPage "255" @default.
- W2331978103 startingPage "245" @default.
- W2331978103 abstract "Background: Early in life, HIV-exposed uninfected (HEU) infants are at an increased risk of morbidity and mortality from infectious disease compared with HIV-unexposed (UE) infants. To improve our understanding of the mechanisms underlying their increased risk, we contrasted innate immune development between HEU and UE infants in a developing world setting, where early life infectious disease risk is exceptionally high. Methods: A prospective longitudinal cohort of HEU and UE newborns was established, and the most detailed characterization to date of HEU infant immune development was performed. Single-cell cytokine production was analyzed by flow cytometry after stimulation of whole blood with pathogen-associated molecular patterns (PAMPs). Results: Monocyte, classical dendritic cell, and plasmacytoid dendritic cell composition was similar between HEU and UE infants throughout the first year of life. However, HEU mononuclear cells mounted an enhanced pro-inflammatory response to PAMP stimulation, both in quantity of cytokine produced per cell and in proportion of responder cells. Significant differences in cytokine production were detected on the single-cell level in a PAMP-specific pattern, but only at 2 and 6 weeks of age; all differences normalized by 12 months of age. Conclusions: This time course of innate immune deviation early in life corresponds to the clinical window of vulnerability to infections in HEU infants and may be at least partially responsible for their increased morbidity and mortality from infectious disease." @default.
- W2331978103 created "2016-06-24" @default.
- W2331978103 creator A5001811559 @default.
- W2331978103 creator A5011540954 @default.
- W2331978103 creator A5015361526 @default.
- W2331978103 creator A5025401318 @default.
- W2331978103 creator A5027714401 @default.
- W2331978103 creator A5031624178 @default.
- W2331978103 creator A5032202399 @default.
- W2331978103 creator A5058716361 @default.
- W2331978103 creator A5064621406 @default.
- W2331978103 creator A5070593890 @default.
- W2331978103 creator A5073468474 @default.
- W2331978103 creator A5089704709 @default.
- W2331978103 date "2014-07-01" @default.
- W2331978103 modified "2023-09-25" @default.
- W2331978103 title "Altered Innate Immune Development in HIV-Exposed Uninfected Infants" @default.
- W2331978103 cites W1600180352 @default.
- W2331978103 cites W1846530466 @default.
- W2331978103 cites W1849265732 @default.
- W2331978103 cites W1963654627 @default.
- W2331978103 cites W1964162189 @default.
- W2331978103 cites W1970390559 @default.
- W2331978103 cites W1984182006 @default.
- W2331978103 cites W1984486655 @default.
- W2331978103 cites W1991722411 @default.
- W2331978103 cites W1996768376 @default.
- W2331978103 cites W2007234139 @default.
- W2331978103 cites W2013399199 @default.
- W2331978103 cites W2013912351 @default.
- W2331978103 cites W2017442023 @default.
- W2331978103 cites W2018079618 @default.
- W2331978103 cites W2018706148 @default.
- W2331978103 cites W2019576909 @default.
- W2331978103 cites W2035221214 @default.
- W2331978103 cites W2037782454 @default.
- W2331978103 cites W2039012729 @default.
- W2331978103 cites W2065432904 @default.
- W2331978103 cites W2066972199 @default.
- W2331978103 cites W2072409135 @default.
- W2331978103 cites W2080076277 @default.
- W2331978103 cites W2080932940 @default.
- W2331978103 cites W2086040638 @default.
- W2331978103 cites W2088599017 @default.
- W2331978103 cites W2088688332 @default.
- W2331978103 cites W2089689912 @default.
- W2331978103 cites W2098196189 @default.
- W2331978103 cites W2100375148 @default.
- W2331978103 cites W2100451798 @default.
- W2331978103 cites W2101932373 @default.
- W2331978103 cites W2112677717 @default.
- W2331978103 cites W2120163056 @default.
- W2331978103 cites W2121365840 @default.
- W2331978103 cites W2127088766 @default.
- W2331978103 cites W2129949204 @default.
- W2331978103 cites W2132762401 @default.
- W2331978103 cites W2150739420 @default.
- W2331978103 cites W2156614434 @default.
- W2331978103 cites W2158404603 @default.
- W2331978103 cites W2161692239 @default.
- W2331978103 cites W2166826933 @default.
- W2331978103 cites W2337587064 @default.
- W2331978103 cites W4233178319 @default.
- W2331978103 doi "https://doi.org/10.1097/qai.0000000000000161" @default.
- W2331978103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4146715" @default.
- W2331978103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24732876" @default.
- W2331978103 hasPublicationYear "2014" @default.
- W2331978103 type Work @default.
- W2331978103 sameAs 2331978103 @default.
- W2331978103 citedByCount "61" @default.
- W2331978103 countsByYear W23319781032014 @default.
- W2331978103 countsByYear W23319781032015 @default.
- W2331978103 countsByYear W23319781032016 @default.
- W2331978103 countsByYear W23319781032017 @default.
- W2331978103 countsByYear W23319781032018 @default.
- W2331978103 countsByYear W23319781032019 @default.
- W2331978103 countsByYear W23319781032020 @default.
- W2331978103 countsByYear W23319781032021 @default.
- W2331978103 countsByYear W23319781032022 @default.
- W2331978103 countsByYear W23319781032023 @default.
- W2331978103 crossrefType "journal-article" @default.
- W2331978103 hasAuthorship W2331978103A5001811559 @default.
- W2331978103 hasAuthorship W2331978103A5011540954 @default.
- W2331978103 hasAuthorship W2331978103A5015361526 @default.
- W2331978103 hasAuthorship W2331978103A5025401318 @default.
- W2331978103 hasAuthorship W2331978103A5027714401 @default.
- W2331978103 hasAuthorship W2331978103A5031624178 @default.
- W2331978103 hasAuthorship W2331978103A5032202399 @default.
- W2331978103 hasAuthorship W2331978103A5058716361 @default.
- W2331978103 hasAuthorship W2331978103A5064621406 @default.
- W2331978103 hasAuthorship W2331978103A5070593890 @default.
- W2331978103 hasAuthorship W2331978103A5073468474 @default.
- W2331978103 hasAuthorship W2331978103A5089704709 @default.
- W2331978103 hasBestOaLocation W23319781031 @default.
- W2331978103 hasConcept C126322002 @default.
- W2331978103 hasConcept C136449434 @default.
- W2331978103 hasConcept C137061746 @default.
- W2331978103 hasConcept C202751555 @default.