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- W2331991796 abstract "We investigated serum complements (CH5O, C3, C4) after aneurysmal subarachnoid hemorrhage in 42 patients over a 2 to 3-week period. For a control, we performed the same examination on 5 patients with non-subarachnoid hemorrhage such as hypertensive intracerebral hemorrhage. There were no remarkable changes of serum complements in the control patients. Twenty-one patients who were admitted to our department after the initial pilot study were divided into two groups: Group A, who received nizofenone fumarate (Econal) which is an antivasospasmotic agent, and Group B, who did not receive the drugs. In Group A, 3 patients showed symptomatic vasospasm and in Group B, one patient showed symptomatic vasospasm. In group A, C4 levels decreased 5 days after the onset of subarachnoid hemorrhage in 8 patients; however, only 2 patients showed symptomatic vasospasm. In vitro study, nizofenone fumarate (Econal) showed anti-complement action in a dose-dependent manner.The above findings suggest that anti-complement therapy might be useful in treating late cerebral vasospasm after subarachnoid hemorrhage." @default.
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- W2331991796 date "1991-01-01" @default.
- W2331991796 modified "2023-10-18" @default.
- W2331991796 title "Therapy for Severe Subarachnoid Hemorrhage" @default.
- W2331991796 doi "https://doi.org/10.2335/scs1987.19.2_173" @default.
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