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- W2332019323 abstract "INTRODUCTION: FOXG1 is a forebrain-specific forkhead box transcription factor, whose high level expression is necessary for telencephalic development in the embryo. Glioblastoma-derived cell cultures also consistently express high levels of FOXG1, and expression in the primary tumour is negatively correlated with patient survival. We and other groups have shown that FOXG1 cooperates with SOX2 to reprogram normal differentiated cells to a neural stem state. METHOD: We have investigated the function of FOXG1 in neural stem cells and their glioblastoma-derived equivalents, and using shRNA knockdown and Crispr/Cas knockout, as well as constitutive and inducible overexpression. We have characterised FOXG1's transcriptional targets using ChIP-Seq and Taqman array assays. We are in the process of exploring FOXG1's reprogramming capabilities in normal and neoplastic brain cell cultures. RESULTS: Functional data supports a role for FOXG1 in establishing and maintaining a neural stem identity, although some established tumour lines show evidence of escape from this regulation. We present a profile of downstream DNA-binding targets, including genes with established roles in self-renewal, lineage selection, cell cycle and chromatin regulation. CONCLUSION: FOXG1 is a candidate master regulator of neural stem cell identity. We believe that its consistent overexpression in GBM cell lines reflects a key role in glioma initiation, and we anticipate that FOXG1's downstream targets will present important novel therapeutic targets." @default.
- W2332019323 created "2016-06-24" @default.
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- W2332019323 date "2014-10-01" @default.
- W2332019323 modified "2023-09-26" @default.
- W2332019323 title "O05 * FOXG1 IS A CANDIDATE TRANSCRIPTIONAL MASTER REGULATOR IN NEURAL STEM CELLS AND GLIOBLASTOMA" @default.
- W2332019323 doi "https://doi.org/10.1093/neuonc/nou250.5" @default.
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