Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332089335> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2332089335 endingPage "142" @default.
- W2332089335 startingPage "139" @default.
- W2332089335 abstract "Autologous stem cell transplantation (SCT) has become standard therapy in high risk stage IV neuroblastoma (NB) patients. Residual NB cells in the bone marrow (BM) shortly before SCT may shape the overall survival.Thus, we sought to thoroughly investigate minimal residual disease (MRD) in BM prior to SCT using conventional and real time RT-PCR for tyrosine hydroxylase (TH) as well as morphology. To avoid influence of residual NB cells in the stem cell harvest, 17 patients transplanted with MRD negative grafts (n=11 CD34-selected and n=6 unmanipulated) are included in the final analysis, only.35% of these patients are alive with a median follow up of 8.6 years. In the BM of 9/17 patients residual NB cells could be detected < 40 d before SCT. These patients had a significant lower overall survival compared to patients without BM involvement based on combined RT-PCR and morphology results (11% vs. 62%, p=0.026) or using RT-PCR, only (p=0.01). In contrast morphology on its own did not lead to a significant discrimination between both groups.Our results obtained in a small cohort of stage IV NB patients suggest that MRD diagnostic in the BM shortly before SCT might be a valuable predictive tool for these patients but requires conformation in a multicenter study." @default.
- W2332089335 created "2016-06-24" @default.
- W2332089335 creator A5003533810 @default.
- W2332089335 creator A5004132358 @default.
- W2332089335 creator A5010755799 @default.
- W2332089335 creator A5016512953 @default.
- W2332089335 creator A5023566246 @default.
- W2332089335 creator A5029816641 @default.
- W2332089335 creator A5033411447 @default.
- W2332089335 creator A5042229264 @default.
- W2332089335 creator A5048657299 @default.
- W2332089335 creator A5058595867 @default.
- W2332089335 creator A5077529752 @default.
- W2332089335 date "2012-02-29" @default.
- W2332089335 modified "2023-09-25" @default.
- W2332089335 title "Impact of Minimal Residual Disease Detection Prior to Autologous Stem Cell Transplantation for Post-transplant Outcome in High Risk Neuroblastoma" @default.
- W2332089335 doi "https://doi.org/10.1055/s-0031-1301334" @default.
- W2332089335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22377741" @default.
- W2332089335 hasPublicationYear "2012" @default.
- W2332089335 type Work @default.
- W2332089335 sameAs 2332089335 @default.
- W2332089335 citedByCount "5" @default.
- W2332089335 countsByYear W23320893352013 @default.
- W2332089335 countsByYear W23320893352015 @default.
- W2332089335 countsByYear W23320893352018 @default.
- W2332089335 countsByYear W23320893352020 @default.
- W2332089335 crossrefType "journal-article" @default.
- W2332089335 hasAuthorship W2332089335A5003533810 @default.
- W2332089335 hasAuthorship W2332089335A5004132358 @default.
- W2332089335 hasAuthorship W2332089335A5010755799 @default.
- W2332089335 hasAuthorship W2332089335A5016512953 @default.
- W2332089335 hasAuthorship W2332089335A5023566246 @default.
- W2332089335 hasAuthorship W2332089335A5029816641 @default.
- W2332089335 hasAuthorship W2332089335A5033411447 @default.
- W2332089335 hasAuthorship W2332089335A5042229264 @default.
- W2332089335 hasAuthorship W2332089335A5048657299 @default.
- W2332089335 hasAuthorship W2332089335A5058595867 @default.
- W2332089335 hasAuthorship W2332089335A5077529752 @default.
- W2332089335 hasConcept C10205521 @default.
- W2332089335 hasConcept C126322002 @default.
- W2332089335 hasConcept C141071460 @default.
- W2332089335 hasConcept C143998085 @default.
- W2332089335 hasConcept C2776715637 @default.
- W2332089335 hasConcept C2777408962 @default.
- W2332089335 hasConcept C2779823535 @default.
- W2332089335 hasConcept C2780007613 @default.
- W2332089335 hasConcept C28328180 @default.
- W2332089335 hasConcept C2911091166 @default.
- W2332089335 hasConcept C54355233 @default.
- W2332089335 hasConcept C71924100 @default.
- W2332089335 hasConcept C72563966 @default.
- W2332089335 hasConcept C81885089 @default.
- W2332089335 hasConcept C86803240 @default.
- W2332089335 hasConcept C90924648 @default.
- W2332089335 hasConceptScore W2332089335C10205521 @default.
- W2332089335 hasConceptScore W2332089335C126322002 @default.
- W2332089335 hasConceptScore W2332089335C141071460 @default.
- W2332089335 hasConceptScore W2332089335C143998085 @default.
- W2332089335 hasConceptScore W2332089335C2776715637 @default.
- W2332089335 hasConceptScore W2332089335C2777408962 @default.
- W2332089335 hasConceptScore W2332089335C2779823535 @default.
- W2332089335 hasConceptScore W2332089335C2780007613 @default.
- W2332089335 hasConceptScore W2332089335C28328180 @default.
- W2332089335 hasConceptScore W2332089335C2911091166 @default.
- W2332089335 hasConceptScore W2332089335C54355233 @default.
- W2332089335 hasConceptScore W2332089335C71924100 @default.
- W2332089335 hasConceptScore W2332089335C72563966 @default.
- W2332089335 hasConceptScore W2332089335C81885089 @default.
- W2332089335 hasConceptScore W2332089335C86803240 @default.
- W2332089335 hasConceptScore W2332089335C90924648 @default.
- W2332089335 hasIssue "03" @default.
- W2332089335 hasLocation W23320893351 @default.
- W2332089335 hasLocation W23320893352 @default.
- W2332089335 hasOpenAccess W2332089335 @default.
- W2332089335 hasPrimaryLocation W23320893351 @default.
- W2332089335 hasRelatedWork W2017162138 @default.
- W2332089335 hasRelatedWork W2055393196 @default.
- W2332089335 hasRelatedWork W2089505157 @default.
- W2332089335 hasRelatedWork W2125213278 @default.
- W2332089335 hasRelatedWork W2339442903 @default.
- W2332089335 hasRelatedWork W2407635825 @default.
- W2332089335 hasRelatedWork W2416169162 @default.
- W2332089335 hasRelatedWork W2416649916 @default.
- W2332089335 hasRelatedWork W2418832270 @default.
- W2332089335 hasRelatedWork W2766393413 @default.
- W2332089335 hasVolume "224" @default.
- W2332089335 isParatext "false" @default.
- W2332089335 isRetracted "false" @default.
- W2332089335 magId "2332089335" @default.
- W2332089335 workType "article" @default.