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- W2332092983 abstract "Placental mesenchymal dysplasia (PMD) is a rare vascular disease associated with intrauterine growth restriction, fetal demise as well as with Beckwick-Wiedemann syndrome. Some neonates present hematologic abnormalities possibly related to consumptive coagulopathy and hemolytic anemia in the placental circulation. A 31 year old pregnant woman on 21st week of pregnancy, the scan showed a fetus smaller than the gestational age, placentomegaly with hypoechoic areas, severe oligoamnios, a hyperechogenic intestine and hemorrhagic damage in the left hemisphere of the cerebellum. The middle cerebral artery speed was higher than average 1.5 MoM for the gestational age. The Karyotype was 46 XX. aCGH analysis revealed no genomic imbalance in the amniocytes. Higher than average concentrations of alfaprotein levels were foun in the amniotic fluid. The TORCH study revealed no abnormalities. Threee weeks later, the ultrasound revealed an intrauterine fetal demise. On admision, the patient's arterial pressure was 130/83 and the urine analysis showed proteinuria of 7.27 g. Blood test showed a normal hepatic profile and hemogram with no coagulation abnormalities. Delivery had to be induced. The autopsy revelaed a left cerebellar infarct and PMD. Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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- W2332092983 date "2014-09-01" @default.
- W2332092983 modified "2023-09-27" @default.
- W2332092983 title "P13.22: Intrauterine growth restriction, cerebellar hematoma and PMD" @default.
- W2332092983 doi "https://doi.org/10.1002/uog.14252" @default.
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