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- W2332098881 abstract "The outstanding symptom in adrenal insufficiency is asthenia. It has been shown experimentally by Gans and Miley,1 who used a nerve muscle preparation, that only 1/16th of the work done in normal rats could be performed in adrenalectomized rats. They did not show whether the seat of this fatigue was in the myoneural junction or in the muscle itself. Certain clinical observations which we have made recently indicate that the nervous system, even the higher centers, may be involved in the fatigue of adrenal insufficiency.In the present investigation, we have studied the effect of cortin on the reflex as well as the peripheral structures. Albino rats of the same strain were adrenalectomized and kept under identical conditions. These were divided into 2 series and matched according to weight and sex. The first series was injected twice daily with 1/2 cc. of cortical extract (40 gm. per cc), while the other series was injected at the same times with the same volumes of isotonic saline. Beginning 2 days after o..." @default.
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- W2332098881 date "1931-11-01" @default.
- W2332098881 modified "2023-09-27" @default.
- W2332098881 title "Effect of Cortin on the Nervous System in Adrenal Insufficiency." @default.
- W2332098881 doi "https://doi.org/10.3181/00379727-29-5765" @default.
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