FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332123533> ?p ?o ?g. }

• W2332123533 endingPage "47" @default.
• W2332123533 startingPage "37" @default.
• W2332123533 abstract "Differentiating P19 embryonal carcinoma (EC) cells transiently express an endogenous activity capable of inducing Pax-3 expression in adjacent P19 stem cells (Pruitt, Development 116, 573-583, 1992). In the present study, expression of this activity in mesodermal cell lineages is demonstrated. First, expression of the mesodermal marker Brachyury correlates with expression of Pax-3-inducing activity. Second, the ability of leukemia inhibitory factor (LIF) to block mesoderm differentiation at two different points is demonstrated and correlated with the inhibition of Pax-3-inducing activity. Finally, two mesodermal cell lines that express Pax-3-inducing activity were derived from P19 EC cells. Each of these lines expresses high levels of the mesodermal marker Brachyury and high levels of Oct-3/4 (which is down-regulated at early times during mesoderm differentiation) suggesting that these lines are early mesodermal derivatives. Unlike EC or embryonic stem cell lines, each of the two mesodermal derivatives autoinduces Hox gene expression on aggregation even in the presence of LIF. Following aggregation, anterior-specific genes are expressed more rapidly than more posterior genes. These observations directly demonstrate the ability of murine mesodermal derivatives to autoinduce Hox gene expression in the absence of signals from other cell lineages. Similar to the Pax-3-inducing activity, signals from mesodermal cell lines were sufficient to induce HOX expression in adjacent P19 stem cells in cell mixing assays. These observations are consistent with the previous suggestion (Blum, M., Gaunt, S. J., Cho, K. W. Y., Steinbeisser, H., Blumberg, B., Bittner, D. and De Robertis, E. M. (1992) Cell 69, 1097-1106) that signals responsible for anterior-posterior organizer activity are localized to the anterior primitive streak mesoderm of the mouse embryo." @default.
• W2332123533 created "2016-06-24" @default.
• W2332123533 creator A5055273811 @default.
• W2332123533 date "1994-01-01" @default.
• W2332123533 modified "2023-10-18" @default.
• W2332123533 title "Primitive streak mesoderm-like cell lines expressing <i>Pax-3</i> and <i>Hox</i> gene autoinducing activities" @default.
• W2332123533 cites W110925524 @default.
• W2332123533 cites W1509585164 @default.
• W2332123533 cites W1869819849 @default.
• W2332123533 cites W1896863876 @default.
• W2332123533 cites W1973921994 @default.
• W2332123533 cites W1979981202 @default.
• W2332123533 cites W1998023087 @default.
• W2332123533 cites W2019350737 @default.
• W2332123533 cites W2036181829 @default.
• W2332123533 cites W2036916162 @default.
• W2332123533 cites W2044918998 @default.
• W2332123533 cites W2045232172 @default.
• W2332123533 cites W2053558740 @default.
• W2332123533 cites W2053702504 @default.
• W2332123533 cites W2058211248 @default.
• W2332123533 cites W2063023858 @default.
• W2332123533 cites W2068634624 @default.
• W2332123533 cites W2071135527 @default.
• W2332123533 cites W2077497255 @default.
• W2332123533 cites W2084099638 @default.
• W2332123533 cites W2086495794 @default.
• W2332123533 cites W2089327546 @default.
• W2332123533 cites W2089522446 @default.
• W2332123533 cites W2117526699 @default.
• W2332123533 cites W2119492233 @default.
• W2332123533 cites W2139556530 @default.
• W2332123533 cites W2147347845 @default.
• W2332123533 cites W2152893516 @default.
• W2332123533 cites W2157651437 @default.
• W2332123533 cites W2166870017 @default.
• W2332123533 cites W2183139415 @default.
• W2332123533 cites W2187361278 @default.
• W2332123533 cites W2576734941 @default.
• W2332123533 cites W74964901 @default.
• W2332123533 doi "https://doi.org/10.1242/dev.120.1.37" @default.
• W2332123533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7907014" @default.
• W2332123533 hasPublicationYear "1994" @default.
• W2332123533 type Work @default.
• W2332123533 sameAs 2332123533 @default.
• W2332123533 citedByCount "15" @default.
• W2332123533 countsByYear W23321235332012 @default.
• W2332123533 crossrefType "journal-article" @default.
• W2332123533 hasAuthorship W2332123533A5055273811 @default.
• W2332123533 hasBestOaLocation W23321235331 @default.
• W2332123533 hasConcept C104317684 @default.
• W2332123533 hasConcept C107459253 @default.
• W2332123533 hasConcept C111039654 @default.
• W2332123533 hasConcept C145103041 @default.
• W2332123533 hasConcept C148738053 @default.
• W2332123533 hasConcept C150194340 @default.
• W2332123533 hasConcept C153911025 @default.
• W2332123533 hasConcept C26805974 @default.
• W2332123533 hasConcept C2780915607 @default.
• W2332123533 hasConcept C28328180 @default.
• W2332123533 hasConcept C46122727 @default.
• W2332123533 hasConcept C54355233 @default.
• W2332123533 hasConcept C66518211 @default.
• W2332123533 hasConcept C86803240 @default.
• W2332123533 hasConcept C95444343 @default.
• W2332123533 hasConceptScore W2332123533C104317684 @default.
• W2332123533 hasConceptScore W2332123533C107459253 @default.
• W2332123533 hasConceptScore W2332123533C111039654 @default.
• W2332123533 hasConceptScore W2332123533C145103041 @default.
• W2332123533 hasConceptScore W2332123533C148738053 @default.
• W2332123533 hasConceptScore W2332123533C150194340 @default.
• W2332123533 hasConceptScore W2332123533C153911025 @default.
• W2332123533 hasConceptScore W2332123533C26805974 @default.
• W2332123533 hasConceptScore W2332123533C2780915607 @default.
• W2332123533 hasConceptScore W2332123533C28328180 @default.
• W2332123533 hasConceptScore W2332123533C46122727 @default.
• W2332123533 hasConceptScore W2332123533C54355233 @default.
• W2332123533 hasConceptScore W2332123533C66518211 @default.
• W2332123533 hasConceptScore W2332123533C86803240 @default.
• W2332123533 hasConceptScore W2332123533C95444343 @default.
• W2332123533 hasIssue "1" @default.
• W2332123533 hasLocation W23321235331 @default.
• W2332123533 hasLocation W23321235332 @default.
• W2332123533 hasOpenAccess W2332123533 @default.
• W2332123533 hasPrimaryLocation W23321235331 @default.
• W2332123533 hasRelatedWork W1493611579 @default.
• W2332123533 hasRelatedWork W1915769919 @default.
• W2332123533 hasRelatedWork W1988318080 @default.
• W2332123533 hasRelatedWork W2009519731 @default.
• W2332123533 hasRelatedWork W2098049105 @default.
• W2332123533 hasRelatedWork W2142602979 @default.
• W2332123533 hasRelatedWork W2332123533 @default.
• W2332123533 hasRelatedWork W2522597563 @default.
• W2332123533 hasRelatedWork W2951944192 @default.
• W2332123533 hasRelatedWork W2187271217 @default.
• W2332123533 hasVolume "120" @default.
• W2332123533 isParatext "false" @default.
• W2332123533 isRetracted "false" @default.

• next