FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332154042> ?p ?o ?g. }

• W2332154042 abstract "Neuroblastoma is the most common extracranial solid tumor in children and originates during development of the peripheral sympathetic nervous system. Advanced-stage disease and a poor outcome are associated with amplification of the MYCN oncogene, often in combination with mutational activation or amplification of another oncogene ALK (anaplastic lymphoma kinase), suggesting that they cooperate in neuroblastoma pathogenesis. To investigate this possibility, we generated a transgenic zebrafish model of neuroblastoma in which human MYCN is expressed under the control of the dopamine-beta-hydroxylase promoter, and show that the resultant tumors recapitulate childhood neuroblastomas histologically, immunohistochemically, and ultrastructurally. Surprisingly, the tumors arise from a subpopulation of neuroblasts that migrate into the adrenal analogue (interrenal gland) in the zebrafish after organogenesis is complete. Coexpression of activated ALK with MYCN markedly increased the frequency of neuroblastoma and accelerated the time of onset, providing conclusive evidence for synergistic interplay between these two oncogenes in neuroblastoma pathogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4296. doi:10.1158/1538-7445.AM2011-4296" @default.
• W2332154042 created "2016-06-24" @default.
• W2332154042 creator A5002000126 @default.
• W2332154042 creator A5003947352 @default.
• W2332154042 creator A5004943053 @default.
• W2332154042 creator A5005126432 @default.
• W2332154042 creator A5005876566 @default.
• W2332154042 creator A5014116572 @default.
• W2332154042 creator A5038148195 @default.
• W2332154042 creator A5038705503 @default.
• W2332154042 creator A5041674013 @default.
• W2332154042 creator A5058975989 @default.
• W2332154042 creator A5060702229 @default.
• W2332154042 creator A5062755510 @default.
• W2332154042 creator A5063101749 @default.
• W2332154042 creator A5063811046 @default.
• W2332154042 creator A5089782174 @default.
• W2332154042 date "2011-04-15" @default.
• W2332154042 modified "2023-10-18" @default.
• W2332154042 title "Abstract 4296: Activated ALK accelerates the onset of neuroblastoma in MYCN-transgenic zebrafish" @default.
• W2332154042 doi "https://doi.org/10.1158/1538-7445.am2011-4296" @default.
• W2332154042 hasPublicationYear "2011" @default.
• W2332154042 type Work @default.
• W2332154042 sameAs 2332154042 @default.
• W2332154042 citedByCount "0" @default.
• W2332154042 crossrefType "proceedings-article" @default.
• W2332154042 hasAuthorship W2332154042A5002000126 @default.
• W2332154042 hasAuthorship W2332154042A5003947352 @default.
• W2332154042 hasAuthorship W2332154042A5004943053 @default.
• W2332154042 hasAuthorship W2332154042A5005126432 @default.
• W2332154042 hasAuthorship W2332154042A5005876566 @default.
• W2332154042 hasAuthorship W2332154042A5014116572 @default.
• W2332154042 hasAuthorship W2332154042A5038148195 @default.
• W2332154042 hasAuthorship W2332154042A5038705503 @default.
• W2332154042 hasAuthorship W2332154042A5041674013 @default.
• W2332154042 hasAuthorship W2332154042A5058975989 @default.
• W2332154042 hasAuthorship W2332154042A5060702229 @default.
• W2332154042 hasAuthorship W2332154042A5062755510 @default.
• W2332154042 hasAuthorship W2332154042A5063101749 @default.
• W2332154042 hasAuthorship W2332154042A5063811046 @default.
• W2332154042 hasAuthorship W2332154042A5089782174 @default.
• W2332154042 hasConcept C104317684 @default.
• W2332154042 hasConcept C117643217 @default.
• W2332154042 hasConcept C121608353 @default.
• W2332154042 hasConcept C126322002 @default.
• W2332154042 hasConcept C126749454 @default.
• W2332154042 hasConcept C142724271 @default.
• W2332154042 hasConcept C2776232967 @default.
• W2332154042 hasConcept C2776256026 @default.
• W2332154042 hasConcept C2776715637 @default.
• W2332154042 hasConcept C2776878037 @default.
• W2332154042 hasConcept C2777956278 @default.
• W2332154042 hasConcept C2779102060 @default.
• W2332154042 hasConcept C2780942790 @default.
• W2332154042 hasConcept C2781018059 @default.
• W2332154042 hasConcept C29537977 @default.
• W2332154042 hasConcept C502942594 @default.
• W2332154042 hasConcept C54355233 @default.
• W2332154042 hasConcept C71924100 @default.
• W2332154042 hasConcept C81885089 @default.
• W2332154042 hasConcept C86803240 @default.
• W2332154042 hasConceptScore W2332154042C104317684 @default.
• W2332154042 hasConceptScore W2332154042C117643217 @default.
• W2332154042 hasConceptScore W2332154042C121608353 @default.
• W2332154042 hasConceptScore W2332154042C126322002 @default.
• W2332154042 hasConceptScore W2332154042C126749454 @default.
• W2332154042 hasConceptScore W2332154042C142724271 @default.
• W2332154042 hasConceptScore W2332154042C2776232967 @default.
• W2332154042 hasConceptScore W2332154042C2776256026 @default.
• W2332154042 hasConceptScore W2332154042C2776715637 @default.
• W2332154042 hasConceptScore W2332154042C2776878037 @default.
• W2332154042 hasConceptScore W2332154042C2777956278 @default.
• W2332154042 hasConceptScore W2332154042C2779102060 @default.
• W2332154042 hasConceptScore W2332154042C2780942790 @default.
• W2332154042 hasConceptScore W2332154042C2781018059 @default.
• W2332154042 hasConceptScore W2332154042C29537977 @default.
• W2332154042 hasConceptScore W2332154042C502942594 @default.
• W2332154042 hasConceptScore W2332154042C54355233 @default.
• W2332154042 hasConceptScore W2332154042C71924100 @default.
• W2332154042 hasConceptScore W2332154042C81885089 @default.
• W2332154042 hasConceptScore W2332154042C86803240 @default.
• W2332154042 hasLocation W23321540421 @default.
• W2332154042 hasOpenAccess W2332154042 @default.
• W2332154042 hasPrimaryLocation W23321540421 @default.
• W2332154042 hasRelatedWork W1547168939 @default.
• W2332154042 hasRelatedWork W1993413458 @default.
• W2332154042 hasRelatedWork W1995315732 @default.
• W2332154042 hasRelatedWork W2023965672 @default.
• W2332154042 hasRelatedWork W2024760098 @default.
• W2332154042 hasRelatedWork W2029126296 @default.
• W2332154042 hasRelatedWork W2036807196 @default.
• W2332154042 hasRelatedWork W2104096565 @default.
• W2332154042 hasRelatedWork W2255091732 @default.
• W2332154042 hasRelatedWork W2313783213 @default.
• W2332154042 hasRelatedWork W2336564600 @default.
• W2332154042 hasRelatedWork W2484168144 @default.
• W2332154042 hasRelatedWork W2498453599 @default.
• W2332154042 hasRelatedWork W2565138600 @default.
• W2332154042 hasRelatedWork W2566810629 @default.
• W2332154042 hasRelatedWork W2567711006 @default.

• next