FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332156741> ?p ?o ?g. }

• W2332156741 endingPage "7" @default.
• W2332156741 startingPage "581" @default.
• W2332156741 abstract "The pharmacokinetics and hepatic metabolism of [3H] ivermectin (IVM) and [3H]cyclosporin A (CSA) were investigated in a subpopulation of the CF-1 mouse stock naturally deficient in mdr1a p-glycoprotein (PGP). A survey of key drug-metabolizing activities in liver fractions from PGP-deficient (-/-) or wild-type (+/+) animals indicated the two subpopulations are not different in hepatic metabolic activity and capacity. Intravenous pharmacokinetics of CSA were identical between the two groups, and results from microsomal incubations indicated similar biotransformation of IVM and CSA in liver. Intestinal excretion of [3H]IVM and [3H]CSA was enhanced in PGP (+/+) animals. Absence of PGP resulted in higher blood concentrations of IVM after oral dosing, suggesting enhanced absorption of IVM in (-/-) mice. Concentrations of [3H]IVM and [3H]CSA were always greater in the brains of (-/-) mice compared with (+/+) mice after either i.v. or oral administration. In contrast, liver concentrations of either compound were not different between (+/+) and (-/-) animals after an i.v. dose. These results show the PGP (-/-) and (+/+) subpopulations of CF-1 mice are useful for studying the role of mdr1a PGP in systemic exposure and tissue disposition of PGP substrates in the absence of metabolism differences." @default.
• W2332156741 created "2016-06-24" @default.
• W2332156741 creator A5008792930 @default.
• W2332156741 creator A5009394304 @default.
• W2332156741 creator A5025204088 @default.
• W2332156741 creator A5032806392 @default.
• W2332156741 creator A5040538402 @default.
• W2332156741 creator A5042118128 @default.
• W2332156741 creator A5051125668 @default.
• W2332156741 creator A5053283016 @default.
• W2332156741 creator A5087902607 @default.
• W2332156741 creator A5088657989 @default.
• W2332156741 creator A5088725266 @default.
• W2332156741 creator A5091610692 @default.
• W2332156741 date "1999-05-01" @default.
• W2332156741 modified "2023-09-26" @default.
• W2332156741 title "Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein." @default.
• W2332156741 cites W1520965071 @default.
• W2332156741 cites W1558311166 @default.
• W2332156741 cites W1581414347 @default.
• W2332156741 cites W1787076927 @default.
• W2332156741 cites W1875749271 @default.
• W2332156741 cites W1891603016 @default.
• W2332156741 cites W1951469402 @default.
• W2332156741 cites W1965959092 @default.
• W2332156741 cites W1979732900 @default.
• W2332156741 cites W1984820569 @default.
• W2332156741 cites W2009961226 @default.
• W2332156741 cites W2011163792 @default.
• W2332156741 cites W2017411996 @default.
• W2332156741 cites W2022435477 @default.
• W2332156741 cites W2062903328 @default.
• W2332156741 cites W2077510533 @default.
• W2332156741 cites W2083418897 @default.
• W2332156741 cites W2108444850 @default.
• W2332156741 cites W2112001901 @default.
• W2332156741 cites W2117771496 @default.
• W2332156741 cites W2136564762 @default.
• W2332156741 cites W47273434 @default.
• W2332156741 cites W633006335 @default.
• W2332156741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10220486" @default.
• W2332156741 hasPublicationYear "1999" @default.
• W2332156741 type Work @default.
• W2332156741 sameAs 2332156741 @default.
• W2332156741 citedByCount "37" @default.
• W2332156741 countsByYear W23321567412012 @default.
• W2332156741 countsByYear W23321567412016 @default.
• W2332156741 countsByYear W23321567412017 @default.
• W2332156741 countsByYear W23321567412020 @default.
• W2332156741 countsByYear W23321567412021 @default.
• W2332156741 countsByYear W23321567412022 @default.
• W2332156741 crossrefType "journal-article" @default.
• W2332156741 hasAuthorship W2332156741A5008792930 @default.
• W2332156741 hasAuthorship W2332156741A5009394304 @default.
• W2332156741 hasAuthorship W2332156741A5025204088 @default.
• W2332156741 hasAuthorship W2332156741A5032806392 @default.
• W2332156741 hasAuthorship W2332156741A5040538402 @default.
• W2332156741 hasAuthorship W2332156741A5042118128 @default.
• W2332156741 hasAuthorship W2332156741A5051125668 @default.
• W2332156741 hasAuthorship W2332156741A5053283016 @default.
• W2332156741 hasAuthorship W2332156741A5087902607 @default.
• W2332156741 hasAuthorship W2332156741A5088657989 @default.
• W2332156741 hasAuthorship W2332156741A5088725266 @default.
• W2332156741 hasAuthorship W2332156741A5091610692 @default.
• W2332156741 hasConcept C10146269 @default.
• W2332156741 hasConcept C112705442 @default.
• W2332156741 hasConcept C126322002 @default.
• W2332156741 hasConcept C133936738 @default.
• W2332156741 hasConcept C134018914 @default.
• W2332156741 hasConcept C181389837 @default.
• W2332156741 hasConcept C185592680 @default.
• W2332156741 hasConcept C202751555 @default.
• W2332156741 hasConcept C2777056448 @default.
• W2332156741 hasConcept C2777928079 @default.
• W2332156741 hasConcept C2778707650 @default.
• W2332156741 hasConcept C2780035454 @default.
• W2332156741 hasConcept C501593827 @default.
• W2332156741 hasConcept C55493867 @default.
• W2332156741 hasConcept C62231903 @default.
• W2332156741 hasConcept C71924100 @default.
• W2332156741 hasConcept C86803240 @default.
• W2332156741 hasConcept C87644729 @default.
• W2332156741 hasConcept C89311334 @default.
• W2332156741 hasConcept C98274493 @default.
• W2332156741 hasConceptScore W2332156741C10146269 @default.
• W2332156741 hasConceptScore W2332156741C112705442 @default.
• W2332156741 hasConceptScore W2332156741C126322002 @default.
• W2332156741 hasConceptScore W2332156741C133936738 @default.
• W2332156741 hasConceptScore W2332156741C134018914 @default.
• W2332156741 hasConceptScore W2332156741C181389837 @default.
• W2332156741 hasConceptScore W2332156741C185592680 @default.
• W2332156741 hasConceptScore W2332156741C202751555 @default.
• W2332156741 hasConceptScore W2332156741C2777056448 @default.
• W2332156741 hasConceptScore W2332156741C2777928079 @default.
• W2332156741 hasConceptScore W2332156741C2778707650 @default.
• W2332156741 hasConceptScore W2332156741C2780035454 @default.
• W2332156741 hasConceptScore W2332156741C501593827 @default.
• W2332156741 hasConceptScore W2332156741C55493867 @default.

• next