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• W2332241189 endingPage "6565" @default.
• W2332241189 startingPage "6550" @default.
• W2332241189 abstract "The aggregation of the microtubule-associated protein, tau, into amyloid fibrils is a hallmark of neurodegenerative diseases such as the tauopathies and Alzheimer’s disease. Since monomeric tau is an intrinsically disordered protein and the polymeric fibrils possess an ordered cross-β core, the aggregation process is known to involve substantial conformational conversion besides growth. The aggregation mechanism of tau in the presence of inducers such as heparin, deciphered using probes such as thioflavin T/S fluorescence, light scattering, and electron microscopy assays, has been shown to conform to ligand-induced nucleation-dependent polymerization. These probes do not, however, distinguish between the processes of conformational conversion and fibril growth. In this study, UV resonance Raman spectroscopy is employed to look directly at signatures of changes in secondary structure and side-chain packing during fibril formation by the four repeat functional domain of tau in the presence of the inducer heparin, at pH 7 and at 37 °C. Changes in the positions and intensities of the amide Raman bands are shown to occur in two distinct stages during the fibril formation process. The first stage of UVRR spectral changes corresponds to the transformation of monomer into early fibrillar aggregates. The second stage corresponds to the transformation of these early fibrillar aggregates into the final, ordered, mature fibrils and during this stage; the processes of conformational conversion and the consolidation of the fibril core occur simultaneously. Delineation of these secondary structural changes accompanying the formation of tau fibrils holds significance for the understanding of generic and tau-specific principles of amyloid assembly." @default.
• W2332241189 created "2016-06-24" @default.
• W2332241189 creator A5002509159 @default.
• W2332241189 creator A5042004457 @default.
• W2332241189 creator A5057549416 @default.
• W2332241189 creator A5080696920 @default.
• W2332241189 date "2014-10-06" @default.
• W2332241189 modified "2023-09-29" @default.
• W2332241189 title "Resonance Raman Spectroscopic Measurements Delineate the Structural Changes that Occur during Tau Fibril Formation" @default.
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