FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332287549> ?p ?o ?g. }

• W2332287549 endingPage "24" @default.
• W2332287549 startingPage "17" @default.
• W2332287549 abstract "Activation of the programmed death 1 (PD1)/PD1 ligand (PDL1) pathway is important for tumor cells to escape from immune control. The clinical efficacy of therapeutic modulation of the PD1-PDL1 pathway has been recently shown in classical Hodgkin lymphoma (cHL), but little is known about the frequency and diagnostic and prognostic importance of PDL1 expression in lymphomas. The available anti-PDL1 antibody clones E1L3N and SP142 were compared, and a large cohort of Hodgkin lymphomas (n = 280) and B-cell lymphomas (n = 619) was examined for PDL1 using E1L3N. The results were correlated with the expression of other phenotypic markers, interphase fluorescence in situ hybridization data of the 9p24.1 region (PDL1 locus), and the clinical outcome. PDL1 was expressed on more than 5% of tumor cells in 70% of cHL, 54% of nodular lymphocyte-predominant Hodgkin lymphoma, and 35% of primary mediastinal B-cell lymphomas; in the latter, PDL1 expression correlated with PDL1 gains (ρ = 0.573). PDL1 was expressed in 31% of primary diffuse large B-cell lymphomas (DLBCLs), whereas most other entities did not express PDL1. In cHL, expression of PDL1 correlated with increased numbers of granzyme + T cells (ρ = 0.251) and CD68 + macrophages (ρ = 0.221) but with decreased numbers of FoxP3 + T cells (ρ = 0.145). In activated B-cell–like DLBCL, PDL1 positively correlated with PD1 + T cells, whereas an inverse correlation with FoxP3 + T cells was seen in the germinal center B-cell–like DLBCL. PDL1 expression can be diagnostically valuable in some gray zones around DLBCL and cHL; it identifies an “immune escape” cluster of cHL and activated B-cell–like DLBCL with increased granzyme + and PD1 + T cells and macrophages and decreased regulatory T cells." @default.
• W2332287549 created "2016-06-24" @default.
• W2332287549 creator A5026353001 @default.
• W2332287549 creator A5041171016 @default.
• W2332287549 creator A5053525375 @default.
• W2332287549 creator A5078150525 @default.
• W2332287549 date "2016-08-01" @default.
• W2332287549 modified "2023-10-17" @default.
• W2332287549 title "Evaluation of the diagnostic and prognostic value of PDL1 expression in Hodgkin and B-cell lymphomas" @default.
• W2332287549 cites W1568356880 @default.
• W2332287549 cites W1580723864 @default.
• W2332287549 cites W1680818974 @default.
• W2332287549 cites W1863071098 @default.
• W2332287549 cites W1898345095 @default.
• W2332287549 cites W1923058706 @default.
• W2332287549 cites W1983718783 @default.
• W2332287549 cites W1986354050 @default.
• W2332287549 cites W1987123970 @default.
• W2332287549 cites W1989904472 @default.
• W2332287549 cites W2003417210 @default.
• W2332287549 cites W2010679787 @default.
• W2332287549 cites W2024979042 @default.
• W2332287549 cites W2033672531 @default.
• W2332287549 cites W2056535502 @default.
• W2332287549 cites W2067198506 @default.
• W2332287549 cites W2079054460 @default.
• W2332287549 cites W2093488543 @default.
• W2332287549 cites W2099175643 @default.
• W2332287549 cites W2101039041 @default.
• W2332287549 cites W2106511606 @default.
• W2332287549 cites W2107736102 @default.
• W2332287549 cites W2108855090 @default.
• W2332287549 cites W2111500154 @default.
• W2332287549 cites W2115091768 @default.
• W2332287549 cites W2125616358 @default.
• W2332287549 cites W2128035403 @default.
• W2332287549 cites W2131628923 @default.
• W2332287549 cites W2139836848 @default.
• W2332287549 cites W2143459396 @default.
• W2332287549 cites W2147240268 @default.
• W2332287549 cites W2153558008 @default.
• W2332287549 cites W2155464214 @default.
• W2332287549 cites W2165983948 @default.
• W2332287549 cites W2168103192 @default.
• W2332287549 cites W2169794517 @default.
• W2332287549 cites W2171741398 @default.
• W2332287549 cites W2178188528 @default.
• W2332287549 cites W2314047154 @default.
• W2332287549 cites W4249076734 @default.
• W2332287549 doi "https://doi.org/10.1016/j.humpath.2016.03.005" @default.
• W2332287549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27045512" @default.
• W2332287549 hasPublicationYear "2016" @default.
• W2332287549 type Work @default.
• W2332287549 sameAs 2332287549 @default.
• W2332287549 citedByCount "129" @default.
• W2332287549 countsByYear W23322875492016 @default.
• W2332287549 countsByYear W23322875492017 @default.
• W2332287549 countsByYear W23322875492018 @default.
• W2332287549 countsByYear W23322875492019 @default.
• W2332287549 countsByYear W23322875492020 @default.
• W2332287549 countsByYear W23322875492021 @default.
• W2332287549 countsByYear W23322875492022 @default.
• W2332287549 countsByYear W23322875492023 @default.
• W2332287549 crossrefType "journal-article" @default.
• W2332287549 hasAuthorship W2332287549A5026353001 @default.
• W2332287549 hasAuthorship W2332287549A5041171016 @default.
• W2332287549 hasAuthorship W2332287549A5053525375 @default.
• W2332287549 hasAuthorship W2332287549A5078150525 @default.
• W2332287549 hasConcept C142724271 @default.
• W2332287549 hasConcept C159654299 @default.
• W2332287549 hasConcept C203014093 @default.
• W2332287549 hasConcept C2776090121 @default.
• W2332287549 hasConcept C2778453870 @default.
• W2332287549 hasConcept C2778559949 @default.
• W2332287549 hasConcept C2779338263 @default.
• W2332287549 hasConcept C2780380082 @default.
• W2332287549 hasConcept C502942594 @default.
• W2332287549 hasConcept C71924100 @default.
• W2332287549 hasConcept C86803240 @default.
• W2332287549 hasConcept C8891405 @default.
• W2332287549 hasConcept C96926380 @default.
• W2332287549 hasConceptScore W2332287549C142724271 @default.
• W2332287549 hasConceptScore W2332287549C159654299 @default.
• W2332287549 hasConceptScore W2332287549C203014093 @default.
• W2332287549 hasConceptScore W2332287549C2776090121 @default.
• W2332287549 hasConceptScore W2332287549C2778453870 @default.
• W2332287549 hasConceptScore W2332287549C2778559949 @default.
• W2332287549 hasConceptScore W2332287549C2779338263 @default.
• W2332287549 hasConceptScore W2332287549C2780380082 @default.
• W2332287549 hasConceptScore W2332287549C502942594 @default.
• W2332287549 hasConceptScore W2332287549C71924100 @default.
• W2332287549 hasConceptScore W2332287549C86803240 @default.
• W2332287549 hasConceptScore W2332287549C8891405 @default.
• W2332287549 hasConceptScore W2332287549C96926380 @default.
• W2332287549 hasLocation W23322875491 @default.
• W2332287549 hasLocation W23322875492 @default.
• W2332287549 hasOpenAccess W2332287549 @default.
• W2332287549 hasPrimaryLocation W23322875491 @default.

• next