Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332300907> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2332300907 abstract "Background We have recently reported cytokine gene profile in kidney allograft recipients during the first week of transplantation. The mRNA transcripts of AIF-1 and IL-18 were enhanced in patient’s blood and particularly podocytes in kidney biopsy samples with rejection episodes. Our aim was to explore the significance of these markers in early kidney dysfunction vs. rejection episodes. We hypothesized that these markers may help to identify patients at high risk of developing DGF or allograft rejection after transplantation. Methods A total of 390 patients who received kidney transplant between 2007 and 2011 at University of Mississippi Medical Center were investigated. Clinical data were stratified, including DGF, stable graft function (SGF), and rejection episodes (RE), which were analyzed on the basis of cellular or antibody mediated rejection. The RE time points were: 36 months. Three blood samples from each patient at different time intervals were tested, using a q-RT-PCR and designated gene primers for inflammatory markers. Results In a global analysis, rejection episode rate was 16.92% (66/390). Separating the data on the basis of rejection time points we observed the following rates: 5.6% (22/66) for rejection episodes within 36 months. The DGF was observed in 13.8%, SGF in 83% of patients after transplantation and 27 (7%) recipients returned to dialysis. IL-18 expression was significantly increased in patients who experienced DGF comparing the samples from pre-transplantation vs. day 3 and 6 post transplantation. AIF-1 was increased but not statistically significant. Both IL-18 and AIF-1 were significantly elevated during the first week of transplantation in patients who later experienced graft loss ( p p Conclusion The mRNA profiles of inflammatory markers observed in this study appeared to be predictive of allograft status and outcome. However, may not be useful to identify patients at high risk of delayed graft function." @default.
- W2332300907 created "2016-06-24" @default.
- W2332300907 creator A5022532931 @default.
- W2332300907 creator A5027662449 @default.
- W2332300907 creator A5051847122 @default.
- W2332300907 creator A5057602228 @default.
- W2332300907 creator A5078393206 @default.
- W2332300907 creator A5086563558 @default.
- W2332300907 creator A5087379661 @default.
- W2332300907 date "2014-10-01" @default.
- W2332300907 modified "2023-09-27" @default.
- W2332300907 title "P043" @default.
- W2332300907 doi "https://doi.org/10.1016/j.humimm.2014.08.105" @default.
- W2332300907 hasPublicationYear "2014" @default.
- W2332300907 type Work @default.
- W2332300907 sameAs 2332300907 @default.
- W2332300907 citedByCount "0" @default.
- W2332300907 crossrefType "journal-article" @default.
- W2332300907 hasAuthorship W2332300907A5022532931 @default.
- W2332300907 hasAuthorship W2332300907A5027662449 @default.
- W2332300907 hasAuthorship W2332300907A5051847122 @default.
- W2332300907 hasAuthorship W2332300907A5057602228 @default.
- W2332300907 hasAuthorship W2332300907A5078393206 @default.
- W2332300907 hasAuthorship W2332300907A5086563558 @default.
- W2332300907 hasAuthorship W2332300907A5087379661 @default.
- W2332300907 hasConcept C126322002 @default.
- W2332300907 hasConcept C126894567 @default.
- W2332300907 hasConcept C159641895 @default.
- W2332300907 hasConcept C2775934546 @default.
- W2332300907 hasConcept C2779978075 @default.
- W2332300907 hasConcept C2780091579 @default.
- W2332300907 hasConcept C2780303639 @default.
- W2332300907 hasConcept C2911091166 @default.
- W2332300907 hasConcept C71924100 @default.
- W2332300907 hasConcept C90924648 @default.
- W2332300907 hasConceptScore W2332300907C126322002 @default.
- W2332300907 hasConceptScore W2332300907C126894567 @default.
- W2332300907 hasConceptScore W2332300907C159641895 @default.
- W2332300907 hasConceptScore W2332300907C2775934546 @default.
- W2332300907 hasConceptScore W2332300907C2779978075 @default.
- W2332300907 hasConceptScore W2332300907C2780091579 @default.
- W2332300907 hasConceptScore W2332300907C2780303639 @default.
- W2332300907 hasConceptScore W2332300907C2911091166 @default.
- W2332300907 hasConceptScore W2332300907C71924100 @default.
- W2332300907 hasConceptScore W2332300907C90924648 @default.
- W2332300907 hasLocation W23323009071 @default.
- W2332300907 hasOpenAccess W2332300907 @default.
- W2332300907 hasPrimaryLocation W23323009071 @default.
- W2332300907 hasRelatedWork W1530409373 @default.
- W2332300907 hasRelatedWork W1533960891 @default.
- W2332300907 hasRelatedWork W1550492812 @default.
- W2332300907 hasRelatedWork W1986434123 @default.
- W2332300907 hasRelatedWork W2046390652 @default.
- W2332300907 hasRelatedWork W2052341243 @default.
- W2332300907 hasRelatedWork W2089233727 @default.
- W2332300907 hasRelatedWork W2342181569 @default.
- W2332300907 hasRelatedWork W2373557891 @default.
- W2332300907 hasRelatedWork W2601080072 @default.
- W2332300907 hasRelatedWork W2771787876 @default.
- W2332300907 hasRelatedWork W2799567751 @default.
- W2332300907 hasRelatedWork W2900887661 @default.
- W2332300907 hasRelatedWork W2972556462 @default.
- W2332300907 hasRelatedWork W2992236737 @default.
- W2332300907 hasRelatedWork W3010374285 @default.
- W2332300907 hasRelatedWork W3012214355 @default.
- W2332300907 hasRelatedWork W3032162505 @default.
- W2332300907 hasRelatedWork W3120116554 @default.
- W2332300907 hasRelatedWork W3126534047 @default.
- W2332300907 isParatext "false" @default.
- W2332300907 isRetracted "false" @default.
- W2332300907 magId "2332300907" @default.
- W2332300907 workType "article" @default.