Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332311945> ?p ?o ?g. }
- W2332311945 abstract "Since their discovery in 2004, neutrophil extracellular traps (NETs) have been characterized as a fundamental host innate immune defense against various pathogens. Released in response to infectious and pro-inflammatory stimuli, NETs can immobilize invading pathogens within a fibrous matrix consisting of DNA, histones, and antimicrobial peptides. Conversely, excessive or dysregulated NET release may hold a variety of detrimental consequences for the host. A fine balance between NET formation and elimination is necessary to sustain a protective effect during infectious challenge. In recent years, a number of microbial virulence factors have been shown to modulate formation of NETs, thereby facilitating colonization or spread within the host. In this mini-review we summarize the contemporary research on the interaction of bacterial exotoxins with neutrophils that modulate NET production, focusing particular attention on consequences for the host. Understanding host-pathogen dynamics in this extracellular battlefield of innate immunity may provide novel therapeutic approaches for infectious and inflammatory disorders." @default.
- W2332311945 created "2016-06-24" @default.
- W2332311945 creator A5020295523 @default.
- W2332311945 creator A5033037817 @default.
- W2332311945 creator A5067852918 @default.
- W2332311945 date "2016-03-30" @default.
- W2332311945 modified "2023-10-13" @default.
- W2332311945 title "Interaction of Bacterial Exotoxins with Neutrophil Extracellular Traps: Impact for the Infected Host" @default.
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- W2332311945 doi "https://doi.org/10.3389/fmicb.2016.00402" @default.
- W2332311945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4811905" @default.
- W2332311945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27064864" @default.
- W2332311945 hasPublicationYear "2016" @default.
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