FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332317340> ?p ?o ?g. }

• W2332317340 endingPage "799" @default.
• W2332317340 startingPage "792" @default.
• W2332317340 abstract "Lysine acetylation serves as an epigenetic marker for myriad cellular processes, such as signaling, differentiation, DNA repair, angiogenesis, and the like. Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD(+)-dependent histone deacetylases that operate as post-translational regulators for the deacetylation of acetyllysine. Here, we discuss the ability for SIRT1 and SIRT2 to deacetylate monoacetylated histone H3 on two separate architectures-the peptide and the nucleosome. In addition, we analyze the site-specificity of SIRT1 and SIRT2 on 10 different monoacetylated histone H3 nucleosomes. By utilizing a rapid screening array, SIRT1 and SIRT2 were found to demonstrate heightened enzymatic activity when incubated with nucleosomal substrates over their peptide counterparts. These two enzymes displayed little site-specificity among the acetyl-nucleosomes screened, contrary to previous expectations, as well. The implication of the overall nonspecificity of SIRT1 and SIRT2 on the nucleosome suggests that these sirtuin enzymes have an adaptive nature, harnessing an ability to respond to various cellular situations, rather than an enzyme specifically designed for a particular task or function." @default.
• W2332317340 created "2016-06-24" @default.
• W2332317340 creator A5056318463 @default.
• W2332317340 creator A5078640786 @default.
• W2332317340 creator A5081625540 @default.
• W2332317340 date "2016-02-05" @default.
• W2332317340 modified "2023-09-24" @default.
• W2332317340 title "Sirtuins 1 and 2 Are Universal Histone Deacetylases" @default.
• W2332317340 cites W1188728470 @default.
• W2332317340 cites W1601675369 @default.
• W2332317340 cites W1965249701 @default.
• W2332317340 cites W1977244638 @default.
• W2332317340 cites W1977919654 @default.
• W2332317340 cites W1984093745 @default.
• W2332317340 cites W1985308585 @default.
• W2332317340 cites W1996395636 @default.
• W2332317340 cites W1997145913 @default.
• W2332317340 cites W1998974491 @default.
• W2332317340 cites W2012233199 @default.
• W2332317340 cites W2024551271 @default.
• W2332317340 cites W2037723157 @default.
• W2332317340 cites W2042749688 @default.
• W2332317340 cites W2043661576 @default.
• W2332317340 cites W2049863902 @default.
• W2332317340 cites W2052130151 @default.
• W2332317340 cites W2053898590 @default.
• W2332317340 cites W2058563561 @default.
• W2332317340 cites W2060768223 @default.
• W2332317340 cites W2061576857 @default.
• W2332317340 cites W2072106835 @default.
• W2332317340 cites W2079514141 @default.
• W2332317340 cites W2083378095 @default.
• W2332317340 cites W2087201991 @default.
• W2332317340 cites W2094807579 @default.
• W2332317340 cites W2097948853 @default.
• W2332317340 cites W2102643362 @default.
• W2332317340 cites W2107733280 @default.
• W2332317340 cites W2118964113 @default.
• W2332317340 cites W2120608933 @default.
• W2332317340 cites W2133130307 @default.
• W2332317340 cites W2165105249 @default.
• W2332317340 cites W2168702014 @default.
• W2332317340 doi "https://doi.org/10.1021/acschembio.5b00886" @default.
• W2332317340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26820517" @default.
• W2332317340 hasPublicationYear "2016" @default.
• W2332317340 type Work @default.
• W2332317340 sameAs 2332317340 @default.
• W2332317340 citedByCount "38" @default.
• W2332317340 countsByYear W23323173402016 @default.
• W2332317340 countsByYear W23323173402017 @default.
• W2332317340 countsByYear W23323173402018 @default.
• W2332317340 countsByYear W23323173402019 @default.
• W2332317340 countsByYear W23323173402020 @default.
• W2332317340 countsByYear W23323173402021 @default.
• W2332317340 countsByYear W23323173402022 @default.
• W2332317340 countsByYear W23323173402023 @default.
• W2332317340 crossrefType "journal-article" @default.
• W2332317340 hasAuthorship W2332317340A5056318463 @default.
• W2332317340 hasAuthorship W2332317340A5078640786 @default.
• W2332317340 hasAuthorship W2332317340A5081625540 @default.
• W2332317340 hasConcept C104317684 @default.
• W2332317340 hasConcept C119157956 @default.
• W2332317340 hasConcept C127561419 @default.
• W2332317340 hasConcept C181199279 @default.
• W2332317340 hasConcept C185592680 @default.
• W2332317340 hasConcept C199848840 @default.
• W2332317340 hasConcept C2776016237 @default.
• W2332317340 hasConcept C2776536020 @default.
• W2332317340 hasConcept C2776745794 @default.
• W2332317340 hasConcept C2780561631 @default.
• W2332317340 hasConcept C41091548 @default.
• W2332317340 hasConcept C515207424 @default.
• W2332317340 hasConcept C552990157 @default.
• W2332317340 hasConcept C55493867 @default.
• W2332317340 hasConcept C64927066 @default.
• W2332317340 hasConcept C70721500 @default.
• W2332317340 hasConcept C75520062 @default.
• W2332317340 hasConcept C84772758 @default.
• W2332317340 hasConcept C86803240 @default.
• W2332317340 hasConcept C95444343 @default.
• W2332317340 hasConceptScore W2332317340C104317684 @default.
• W2332317340 hasConceptScore W2332317340C119157956 @default.
• W2332317340 hasConceptScore W2332317340C127561419 @default.
• W2332317340 hasConceptScore W2332317340C181199279 @default.
• W2332317340 hasConceptScore W2332317340C185592680 @default.
• W2332317340 hasConceptScore W2332317340C199848840 @default.
• W2332317340 hasConceptScore W2332317340C2776016237 @default.
• W2332317340 hasConceptScore W2332317340C2776536020 @default.
• W2332317340 hasConceptScore W2332317340C2776745794 @default.
• W2332317340 hasConceptScore W2332317340C2780561631 @default.
• W2332317340 hasConceptScore W2332317340C41091548 @default.
• W2332317340 hasConceptScore W2332317340C515207424 @default.
• W2332317340 hasConceptScore W2332317340C552990157 @default.
• W2332317340 hasConceptScore W2332317340C55493867 @default.
• W2332317340 hasConceptScore W2332317340C64927066 @default.
• W2332317340 hasConceptScore W2332317340C70721500 @default.
• W2332317340 hasConceptScore W2332317340C75520062 @default.
• W2332317340 hasConceptScore W2332317340C84772758 @default.

• next