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- W2332320905 abstract "Thyroid goiters and adenomas are frequent diseases of the follicular thyroid epithelium, whereas follicular thyroid carcinomas are rather rare. In contrast to the malignant thyroid tumors, follicular thyroid goiters and adenomas are cytogenetically well examined epithelial tumors. Cytogenetic aberrations occurred in about 20% of these lesions and were divided in different subgroups. One of these subgroups is characterized by structural rearrangements involving chromosomal band 2p21. Recently, we mapped the breakpoints in two established cell lines from benign thyroid tumors showing translocations in this region within a segment of about 450 kb flanked by BAC-clones 339H12 and 1069E24. By 3’-RACE analyses on these cell lines we have identified fusion genes consisting of the thyroid adenoma associated gene (THADA) located in 2p21 and unknown genes located in 3p25 and 7p15. In both fusion genes (THADA-FUS3p and THADA-FUS7p) ectopic sequences mapping within the breakpoint regions of the translocation partners are fused to exon 28 of THADA. Thus the 3’-part of THADA is truncated and there seems to be evidence that the truncation of the gene and the protein rather than the fusion to a particular coding sequence is the critical event. Due to the possible function of THADA as a death receptor interacting protein we presume that the truncation of the 3’-part may lead to an altered apoptosis induction. This may cause an increased proliferation of epithelial cells in benign thyroid tumors with 2p21 aberration. Thus further elucidation of the function of the THADA protein may be helpful to get insights in the pathogenesis of benign thyroid tumors and possibly into benign tumors in general." @default.
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- W2332320905 date "2004-03-02" @default.
- W2332320905 modified "2023-10-18" @default.
- W2332320905 title "Truncations of the THADA gene are involved in the development of thyroid adenomas with 2p21 aberrations" @default.
- W2332320905 doi "https://doi.org/10.1055/s-2004-819070" @default.
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