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- W2332327503 abstract "Radioligand binding studies have detected α1A- and α1B-adrenergic receptors (AR) in rat heart, but the ligands available for these studies lack the sensitivity and specificity needed to map possible differences in α1-AR subtype expression. We therefore used competitive reverse transcriptase-polymerase chain reaction (RT-PCR) techniques to measure steady-state amounts of α1-AR messenger RNA (mRNA) subtypes in tissue dissected from several regions of rat heart. We detected mRNA for α1A-, α1B-, and α1D-AR in each region. Irrespective of the αAR subtype, the total number of α1-AR transcripts has the following regional rank order: left ventricular papillary muscle > left ventricle > left atrium > apex > right ventricle > ventricular septum > right atria. Among the regions, the fractional contribution of α1A-, α1B-, and α1D-AR mRNA to the total amount of α1-AR displays considerable variability. The α1B-AR mRNA accounts for >50% of the total α1-AR mRNA in all regions except the ventricular septum. There are also significant percentages of α1A-AR in each region, especially in the papillary muscle (48%) and ventricular septum (48%). The α1D-AR mRNA transcripts are found in comparatively low numbers; their highest levels (18% of total) were found in the right ventricle. These differences in α1-AR mRNA expression may contribute to the observed regional differences in myocardial responses to α1-AR agonists and antagonists." @default.
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- W2332327503 date "1998-07-01" @default.
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- W2332327503 title "Distribution of α1-Adrenergic Receptor mRNA Species in Rat Heart" @default.
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- W2332327503 doi "https://doi.org/10.1097/00005344-199807000-00018" @default.
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