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• W2332334180 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCBackground: Hormone therapy (HT) may prevent colorectal cancer (CRC), but the molecular mechanisms have not been fully defined. Expression of estrogen receptor beta (ERβ) has been associated with CRC stage and survival and may influence HT-related prevention pathways. In this prospective cohort study, we examined HT-associated CRC risk by ERβ protein expression levels in the population-based Iowa Women's Health Study (IWHS).Methods: The IWHS recruited 41,836 randomly selected Iowa women, ages 55-69 years, with a valid driver's license at study entry (1986). Exposure variables were assessed at baseline, by self-report. Incident CRC cases were ascertained by annual linkage with the Iowa Cancer Registry. Archived, paraffin-embedded tissue specimens were collected from 732 CRC cases, diagnosed through 12/31/2002, for molecular epidemiology studies. HT was categorized as never, former, and current and with durations of 5 years. ERβ protein expression was determined by immunohistochemistry on tissue microarrays. For each tumor core, both staining intensity (0-3) and proportion of cells stained (0-5) were scored. These two scores were added to determine negative (0), low (1-5) or high (6-8) ERβ protein expression levels. Multivariate Cox regression models were fit to estimate relative risks (RRs) and 95% confidence intervals (CIs).Results: Complete HT and ERβ data were available from 484 CRC cases. Associations between HT and CRC subtypes defined by ERβ expression level are shown in the Table.Conclusions: Data from the IWHS cohort suggest that current and longer-duration HT exposure favorably influence the risk for ERβ-neg or ERβ-low CRC cases to a greater degree than ERβ-high CRC cases. Further investigation is required to confirm these observations, and to clarify the underlying mechanisms.| | | ERβ Neg or Low | ERβ High ||:--------------- | ------------ | -------------- | ---------------- | --------- || Hormone Therapy | Person years | Events, N | RR* (95% CI) | Events, N | RR* (95% CI) || Never | 341377 | 128 | 1.00 (Ref.) | 196 | 1.00 (Ref.) || Ever | 212696 | 62 | 0.74 (0.54,1.03) | 98 | 0.82 (0.63,1.07) || Former | 151535 | 48 | 0.79 (0.56,1.12) | 67 | 0.73 (0.54,0.99) || Current | 61161 | 14 | 0.60 (0.33,1.09) | 31 | 1.11 (0.74,1.64) || P-trend | | | 0.05 | | 0.52 || Duration || < = 5yrs | 148704 | 47 | 0.84 (0.59,1.19) | 68 | 0.80 (0.60,1.08) || >5yrs | 60064 | 14 | 0.5 (0.26,0.93) | 28 | 0.89 (0.59,1.34) || P-trend | | | 0.03 | | 0.25 |Citation Format: Lori S. Tillmans, Robert A. Vierkant, Alice H. Wang, Charles F. Lynch, Kristin E. Anderson, Amy J. French, Robert W. Haile, John D. Potter, Susan L. Slager, Thomas C. Smyrk, Stephen N. Thibodeau, James R. Cerhan, Paul J. Limburg. Hormone therapy and incident colorectal cancer risk by ER beta protein expression level in a population-based cohort of older women. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3652. doi:10.1158/1538-7445.AM2013-3652" @default.
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• W2332334180 date "2013-04-15" @default.
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• W2332334180 title "Abstract 3652: Hormone therapy and incident colorectal cancer risk by ER beta protein expression level in a population-based cohort of older women." @default.
• W2332334180 doi "https://doi.org/10.1158/1538-7445.am2013-3652" @default.
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