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- W2332339892 abstract "212 The purpose of this study is to measure the effect Tacrolimus (FK506), Mycophenolate Mofetil (MMF), Prednisone combination therapy has on rejection of muscle and bone in a pre-clinical composite tissue allotransplant (CTA) model. We used CTA flaps created on the forelimbs of 22 pigs. The flaps consisted of radial bone, flexor muscle/tendon, supplying nerves and vessels and skin. For immunosuppression, we used a combination of orally administered FK506 (15 mg/kg/d), MMF (500 mg/d) and Prednisone (0.2 mg/kg/d). Animals were allotted into 3 groups: Group I (n=6) animals received FK506/MMF/Prednisone therapy and a CTA, Group II (n=4) animals received no drugs and a CTA, and Group III (n=12) animals served as controls receiving no therapy and no CTA. Group I animals were followed for 90 days. At the end of the experiment, animals were euthanized and bone, muscle, and tendon specimens were harvested, fixed in formaldehyde (10%) and stained with H&E. The following parameters were analyzed in all specimens in a blind fashion; bone-mononuclear infiltration, fibroblastic proliferation, irregular cortical thickening, nonviable trabeculae, intratrabecular fibrosis, filigree osteoid formation, and hemorrhage/necrosis, muscle-mononuclear infiltration, fibroblastic proliferation/replaced muscle fibers, muscle fiber degeneration, myocyte necrosis, and vascular inflammation, tendon-mononuclear infiltration, perivascular inflammation, fibrosis, degeneration, and necrosis.(Table)TableBased on our results in this pre-clinical CTA model we conclude, that FK 506 based combination therapy reduces the incidence of acute rejection episodes in bone, muscle and tendon. This effect was more pronounced in bone and tendon than in muscle." @default.
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- W2332339892 date "1999-04-01" @default.
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- W2332339892 title "The Effect of Tacrolimus Based Combination Therapy on Muscle and Bone Rejection in a Pre-Clinical Composite Tissue Allograft Model" @default.
- W2332339892 doi "https://doi.org/10.1097/00007890-199904150-00240" @default.
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