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• W2332370422 abstract "While many differences in hippocampal anatomy have been described between species, it is typically not clear if they are specific to a particular species and related to functional requirements or if they are shared by species of larger taxonomic units. Without such information, it is difficult to infer how anatomical differences may impact on hippocampal function, because multiple taxonomic levels need to be considered to associate behavioral and anatomical changes. To provide information on anatomical changes within and across taxonomic ranks, we present a quantitative assessment of hippocampal principal cell populations in 20 species or strain groups, with emphasis on rodents, the taxonomic group that provides most animals used in laboratory research. Of special interest is the importance of adult hippocampal neurogenesis (AHN) in species-specific adaptations relative to other cell populations. Correspondence analysis of cell numbers shows that across taxonomic units, phylogenetically related species cluster together, sharing similar proportions of principal cell populations. CA3 and hilus are strong separators that place rodent species into a tight cluster based on their relatively large CA3 and small hilus while non-rodent species (including humans and non-human primates) are placed on the opposite side of the spectrum. Hilus and CA3 are also separators within rodents, with a very large CA3 and rather small hilar cell populations separating mole-rats from other rodents that, in turn, are separated from each other by smaller changes in the proportions of CA1 and granule cells. When adult neurogenesis is included, the relatively small populations of young neurons, proliferating cells and hilar neurons become main drivers of taxonomic separation within rodents. The observations provide challenges to the computational modeling of hippocampal function, suggest differences in the organization of hippocampal information streams in rodent and non-rodent species, and support emerging concepts of functional and structural interactions between CA3 and the dentate gyrus." @default.
• W2332370422 created "2016-06-24" @default.
• W2332370422 creator A5001786704 @default.
• W2332370422 creator A5010835452 @default.
• W2332370422 creator A5077363055 @default.
• W2332370422 creator A5078766625 @default.
• W2332370422 date "2016-03-09" @default.
• W2332370422 modified "2023-10-01" @default.
• W2332370422 title "Taxonomic Separation of Hippocampal Networks: Principal Cell Populations and Adult Neurogenesis" @default.
• W2332370422 cites W1506123947 @default.
• W2332370422 cites W1535310858 @default.
• W2332370422 cites W1539532151 @default.
• W2332370422 cites W1556707181 @default.
• W2332370422 cites W1570326401 @default.
• W2332370422 cites W1571273117 @default.
• W2332370422 cites W1576581762 @default.
• W2332370422 cites W1577735764 @default.
• W2332370422 cites W1637819512 @default.
• W2332370422 cites W1669925514 @default.
• W2332370422 cites W1679410327 @default.
• W2332370422 cites W1779226031 @default.
• W2332370422 cites W1779596816 @default.
• W2332370422 cites W1827373965 @default.
• W2332370422 cites W1904955806 @default.
• W2332370422 cites W1964423835 @default.
• W2332370422 cites W1965351418 @default.
• W2332370422 cites W1969949618 @default.
• W2332370422 cites W1972155337 @default.
• W2332370422 cites W1975630693 @default.
• W2332370422 cites W1975648411 @default.
• W2332370422 cites W1979283544 @default.
• W2332370422 cites W1980718821 @default.
• W2332370422 cites W1981697483 @default.
• W2332370422 cites W1984325684 @default.
• W2332370422 cites W1986414879 @default.
• W2332370422 cites W1987243812 @default.
• W2332370422 cites W1988489456 @default.
• W2332370422 cites W1989398031 @default.
• W2332370422 cites W1990626187 @default.
• W2332370422 cites W1992949974 @default.
• W2332370422 cites W1995188451 @default.
• W2332370422 cites W1997629431 @default.
• W2332370422 cites W1999446466 @default.
• W2332370422 cites W2002481366 @default.
• W2332370422 cites W2005239979 @default.
• W2332370422 cites W2008468514 @default.
• W2332370422 cites W2008594080 @default.
• W2332370422 cites W2009083928 @default.
• W2332370422 cites W2012132665 @default.
• W2332370422 cites W2012252346 @default.
• W2332370422 cites W2012530843 @default.
• W2332370422 cites W2014031535 @default.
• W2332370422 cites W2014892312 @default.
• W2332370422 cites W2019677463 @default.
• W2332370422 cites W2019970707 @default.
• W2332370422 cites W2020883284 @default.
• W2332370422 cites W2025839511 @default.
• W2332370422 cites W2026449956 @default.
• W2332370422 cites W2029930491 @default.
• W2332370422 cites W2030920999 @default.
• W2332370422 cites W2031190340 @default.
• W2332370422 cites W2033044289 @default.
• W2332370422 cites W2034664267 @default.
• W2332370422 cites W2035248798 @default.
• W2332370422 cites W2036773579 @default.
• W2332370422 cites W2037367554 @default.
• W2332370422 cites W2038220499 @default.
• W2332370422 cites W2040245119 @default.
• W2332370422 cites W2043699984 @default.
• W2332370422 cites W2048597452 @default.
• W2332370422 cites W2054364249 @default.
• W2332370422 cites W2056177071 @default.
• W2332370422 cites W2059332720 @default.
• W2332370422 cites W2060789079 @default.
• W2332370422 cites W2066379273 @default.
• W2332370422 cites W2069769925 @default.
• W2332370422 cites W2070368256 @default.
• W2332370422 cites W2074304774 @default.
• W2332370422 cites W2075294308 @default.
• W2332370422 cites W2075869459 @default.
• W2332370422 cites W2078624194 @default.
• W2332370422 cites W2078751290 @default.
• W2332370422 cites W2079300768 @default.
• W2332370422 cites W2080030919 @default.
• W2332370422 cites W2080341245 @default.
• W2332370422 cites W2082455255 @default.
• W2332370422 cites W2084997223 @default.
• W2332370422 cites W2087874336 @default.
• W2332370422 cites W2088042096 @default.
• W2332370422 cites W2088189569 @default.
• W2332370422 cites W2090080279 @default.
• W2332370422 cites W2090207253 @default.
• W2332370422 cites W2091474780 @default.
• W2332370422 cites W2093143193 @default.
• W2332370422 cites W2093672151 @default.
• W2332370422 cites W2095495996 @default.
• W2332370422 cites W2098282121 @default.
• W2332370422 cites W2099005226 @default.
• W2332370422 cites W2100368536 @default.
• W2332370422 cites W2102137096 @default.

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