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• W2332389724 abstract "Event Abstract Back to Event The NO-cGMP-PKG signal pathway is involved in the tentacle regeneration of the snail, Helix pomatia Z. Serfőző1* 1 Balaton Limnological Research Institute, Hungarian Academy of Sciences, Department of Experimental Zoology, Hungary Nitric oxide (NO) signaling was followed in a snail model for neural regeneration. In the tentacle ganglion of the snail, Helix pomatia the NOS activity was found 120.3±7.2 nmol nitrite/µg protein/h measured by the sensitized Griess method. 0.1mM L-NAME blocked this activity by 85%. After 9 weeks of the tentacle regeneration NOS activity was reappeared, and began to increase up to 894.5±14.5 nmol nitrite/µg protein/h found at the 13th week, and normalized by the 15th week with a 152.5±7.2 nmol nitrite/µg protein/h activity. NOS protein level was changed similar to activity as revealed by immunoblot experiments. cGMP EIA showed that the intact tentacle contains 12.3±4.5 pmol/mg protein cGMP which could be increased by 472±15% and 629±45% when the tentacle homogenate was incubated with 1mM SNAP and 10 µM YC-1, respectively, in the presence of 1mM IBMX. Stimulated cGMP production was inhibited by 10 µM ODQ. cGMP level of the regenerating tentacle was peaking (38.4±8.4 pmol/mg protein) at the 13th week. ELISA assay of the phosphorylated PKG substrate Akt revealed that PKG mean activity was the highest between the 1-5 weeks and the 11-15 weeks of regeneration (212±25%, and 152±20% of control, respectively). Using the PKG inhibitor peptide, 1 µM RKRARKE indicated that other kinases also possesses significant activity at the early phase of regeneration. Our observations supported that the NO-cGMP-PKG signal pathway is involved in neural regeneration. Acknowledgements Funded by OTKA grant PD75276. Keywords: Molecular and cellular neurobiology, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Molecular and cellular neurobiology Citation: Serfőző Z (2011). The NO-cGMP-PKG signal pathway is involved in the tentacle regeneration of the snail, Helix pomatia. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00031 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. Z. Serfőző, Balaton Limnological Research Institute, Hungarian Academy of Sciences, Department of Experimental Zoology, Tihany, Hungary, serfozo@tres.blki.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Z. Serfőző Google Z. Serfőző Google Scholar Z. Serfőző PubMed Z. Serfőző Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2332389724 title "The NO-cGMP-PKG signal pathway is involved in the tentacle regeneration of the snail, Helix pomatia" @default.
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