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- W2332443082 abstract "<h3>Background</h3> In children with asthma, web-based monitoring and inflammation-driven therapy may lead to improved asthma control and reduction in medications. However, the cost-effectiveness of these monitoring strategies is yet unknown. <h3>Objective</h3> We assessed the cost-effectiveness of web-based monthly monitoring and of 4-monthly monitoring of FE<sub>NO</sub> as compared with standard care. <h3>Methods</h3> An economic evaluation was performed alongside a randomised controlled multicentre trial with a 1-year follow-up. Two hundred and seventy-two children with asthma, aged 4–18 years, were randomised to one of three strategies. In standard care, treatment was adapted according to Asthma Control Test (ACT) at 4-monthly visits, in the web-based strategy also according to web-ACT at 1 month intervals, and in the FE<sub>NO</sub>-based strategy according to ACT and FE<sub>NO</sub> at 4-monthly visits. Outcome measures were patient utilities, healthcare costs, societal costs and incremental cost per quality-adjusted life year (QALY) gained. <h3>Results</h3> No statistically significant differences were found in QALYs and costs between the three strategies. The web-based strategy had 77% chance of being most cost-effective from a healthcare perspective at a willingness to pay a generally accepted €40 000/QALY. The FE<sub>NO</sub>-based strategy had 83% chance of being most cost-effective at €40 000/QALY from a societal perspective. <h3>Conclusions</h3> Economically, web-based monitoring was preferred from a healthcare perspective, while the FE<sub>NO</sub>-based strategy was preferred from a societal perspective, although in QALYs and costs no statistically significant changes were found as compared with standard care. As clinical outcomes also favoured the web-based and FE<sub>NO</sub>-based strategies, these strategies may be useful additions to standard care. <h3>Trial registration number</h3> Netherlands Trial Register (NTR1995)." @default.
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- W2332443082 date "2016-04-05" @default.
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- W2332443082 title "Cost-effectiveness of FE<sub>NO</sub>-based and web-based monitoring in paediatric asthma management: a randomised controlled trial" @default.
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- W2332443082 doi "https://doi.org/10.1136/thoraxjnl-2015-207593" @default.
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