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- W2332451099 abstract "Bioactive compounds capable of interacting with tubulins and microtubules represent powerful weapons in cancer chemotherapy. Most of these compounds, including the well-established chemotherapeutic agents colchicine (1), podophyllotoxin (3), vinblastine (4) and vincristine (5) that interfere with the formation and growth of microtubules, or Taxol (11) and the epothilones (12-13), which promote tubulin polymerization and stabilize microtubules, share an interaction with β-tubulin, one of the two subunits of the globular heterodimeric protein tubulin. In contrast, few compounds have been identified as interacting with α-tubulin. A select group of natural compounds are pironetin (18) and the hemiasterlins, and the synthetic compounds cyanoacrylates (21-22), dinitroanilines (23-25) and tetrahydrofuranyl derivatives COBRA-0 (133) and COBRA-1 (26). In addition to their interaction with the α-tubulin subunit, all these compounds share the capacity of destabilizing microtubules. In the present review, we will discuss the most relevant aspects of the biology and chemistry of these compounds, with an emphasis on their antiproliferative properties and potential as anticancer drugs. Keywords: Guanosin triphosphate, Camphorsulfonic acid, Butyllithium, Colchicine Binding-like Compounds, COBRA-1, Hemiasterlins" @default.
- W2332451099 created "2016-06-24" @default.
- W2332451099 creator A5013846245 @default.
- W2332451099 creator A5046740490 @default.
- W2332451099 creator A5056568607 @default.
- W2332451099 date "2006-09-01" @default.
- W2332451099 modified "2023-10-18" @default.
- W2332451099 title "Chemistry and Biology of Novel Microtubule-Destabilizing Agents that Bind α-Tubulin" @default.
- W2332451099 cites W122719748 @default.
- W2332451099 cites W1530572244 @default.
- W2332451099 cites W1545989348 @default.
- W2332451099 cites W1547132539 @default.
- W2332451099 cites W159318255 @default.
- W2332451099 cites W1623861753 @default.
- W2332451099 cites W1713351558 @default.
- W2332451099 cites W1885901959 @default.
- W2332451099 cites W1917160910 @default.
- W2332451099 cites W1965137443 @default.
- W2332451099 cites W1965404941 @default.
- W2332451099 cites W1965669201 @default.
- W2332451099 cites W1966022271 @default.
- W2332451099 cites W1966404502 @default.
- W2332451099 cites W1967245425 @default.
- W2332451099 cites W1968720837 @default.
- W2332451099 cites W1977117721 @default.
- W2332451099 cites W1981534406 @default.
- W2332451099 cites W1981806030 @default.
- W2332451099 cites W1982485940 @default.
- W2332451099 cites W1982947338 @default.
- W2332451099 cites W1982977272 @default.
- W2332451099 cites W1985499212 @default.
- W2332451099 cites W1986393243 @default.
- W2332451099 cites W1986571317 @default.
- W2332451099 cites W1988369885 @default.
- W2332451099 cites W1991399276 @default.
- W2332451099 cites W1994162165 @default.
- W2332451099 cites W1996126627 @default.
- W2332451099 cites W1998422891 @default.
- W2332451099 cites W2000716186 @default.
- W2332451099 cites W2001058978 @default.
- W2332451099 cites W2003503929 @default.
- W2332451099 cites W2003747331 @default.
- W2332451099 cites W2004777236 @default.
- W2332451099 cites W2004912903 @default.
- W2332451099 cites W2007469912 @default.
- W2332451099 cites W2009087723 @default.
- W2332451099 cites W2009523558 @default.
- W2332451099 cites W2009785870 @default.
- W2332451099 cites W2010753146 @default.
- W2332451099 cites W2011239690 @default.
- W2332451099 cites W2012232448 @default.
- W2332451099 cites W2013537032 @default.
- W2332451099 cites W2017167372 @default.
- W2332451099 cites W2017553996 @default.
- W2332451099 cites W2019430955 @default.
- W2332451099 cites W2020721450 @default.
- W2332451099 cites W2023936614 @default.
- W2332451099 cites W2029549636 @default.
- W2332451099 cites W2029687996 @default.
- W2332451099 cites W2033702956 @default.
- W2332451099 cites W2034140820 @default.
- W2332451099 cites W2037490361 @default.
- W2332451099 cites W2043172025 @default.
- W2332451099 cites W2045824232 @default.
- W2332451099 cites W2048188756 @default.
- W2332451099 cites W2048853911 @default.
- W2332451099 cites W2055785743 @default.
- W2332451099 cites W2062795675 @default.
- W2332451099 cites W2063202715 @default.
- W2332451099 cites W2064571598 @default.
- W2332451099 cites W2064967022 @default.
- W2332451099 cites W2065091191 @default.
- W2332451099 cites W2067071751 @default.
- W2332451099 cites W2067278945 @default.
- W2332451099 cites W2067299834 @default.
- W2332451099 cites W2070964736 @default.
- W2332451099 cites W2072830954 @default.
- W2332451099 cites W2076536487 @default.
- W2332451099 cites W2078347268 @default.
- W2332451099 cites W2082965112 @default.
- W2332451099 cites W2084546943 @default.
- W2332451099 cites W2085257251 @default.
- W2332451099 cites W2085328130 @default.
- W2332451099 cites W2086654490 @default.
- W2332451099 cites W2087259918 @default.
- W2332451099 cites W2089248551 @default.
- W2332451099 cites W2090934768 @default.
- W2332451099 cites W2092697567 @default.
- W2332451099 cites W2093317402 @default.
- W2332451099 cites W2094196494 @default.
- W2332451099 cites W2099402178 @default.
- W2332451099 cites W2099985384 @default.
- W2332451099 cites W2103590067 @default.
- W2332451099 cites W2117931147 @default.
- W2332451099 cites W2122631316 @default.
- W2332451099 cites W2125089526 @default.
- W2332451099 cites W2129957850 @default.
- W2332451099 cites W2133260631 @default.