Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332459367> ?p ?o ?g. }
- W2332459367 endingPage "937" @default.
- W2332459367 startingPage "922" @default.
- W2332459367 abstract "Bacterial capsular polysaccharides are components of many modern vaccines, but they are weakly immunogenic. Herein, we describe the delivery of pneumococcal capsular polysaccharide serotype-1 (PCP-1) in polylactide polymeric particles to enhance its immunogenicity. Immunization with PCP-1-entrapped particles elicited long-term memory antibody responses from a single intramuscular injection. PCP-1-entrapped nanoparticles (NPs) elicited significantly higher anti-PCP-1 IgG responses than that observed with soluble and microparticles (MPs) formulations. Delivering PCP-1 and pneumococcal proteins in same particles did not improve the IgG response. The sera of animals immunized with PCP-1-entrapped particles promoted efficient opsonophagocytosis of pneumococci by macrophages. Single-dose immunization with PCP-1-entrapped particles conferred a long-term serotype-specific protection against lethal pneumococcal challenge. The higher immunogenicity of PCP-1 nanoparticles showed correlation with enhanced uptake by antigen-presenting cells. The results highlight the potential of polymeric nanoparticles as an efficient means of presenting polysaccharide antigens to the immune system." @default.
- W2332459367 created "2016-06-24" @default.
- W2332459367 creator A5030272776 @default.
- W2332459367 creator A5048584299 @default.
- W2332459367 creator A5053639264 @default.
- W2332459367 creator A5060003459 @default.
- W2332459367 creator A5084633112 @default.
- W2332459367 date "2014-01-29" @default.
- W2332459367 modified "2023-10-16" @default.
- W2332459367 title "Delivery of Polysaccharides Using Polymer Particles: Implications on Size-Dependent Immunogenicity, Opsonophagocytosis, and Protective Immunity" @default.
- W2332459367 cites W1604192625 @default.
- W2332459367 cites W1967211746 @default.
- W2332459367 cites W1970238011 @default.
- W2332459367 cites W1973482993 @default.
- W2332459367 cites W1980073782 @default.
- W2332459367 cites W1988183869 @default.
- W2332459367 cites W1988422289 @default.
- W2332459367 cites W1991701295 @default.
- W2332459367 cites W1998926818 @default.
- W2332459367 cites W1999494484 @default.
- W2332459367 cites W2001039642 @default.
- W2332459367 cites W2003966139 @default.
- W2332459367 cites W2008570575 @default.
- W2332459367 cites W2009069733 @default.
- W2332459367 cites W2018025669 @default.
- W2332459367 cites W2025868400 @default.
- W2332459367 cites W2029404265 @default.
- W2332459367 cites W2031763448 @default.
- W2332459367 cites W2039472971 @default.
- W2332459367 cites W2042791775 @default.
- W2332459367 cites W2045106645 @default.
- W2332459367 cites W2055861239 @default.
- W2332459367 cites W2056616704 @default.
- W2332459367 cites W2059674129 @default.
- W2332459367 cites W2066133524 @default.
- W2332459367 cites W2068846148 @default.
- W2332459367 cites W2072753827 @default.
- W2332459367 cites W2079081917 @default.
- W2332459367 cites W2079485319 @default.
- W2332459367 cites W2102502668 @default.
- W2332459367 cites W2106183630 @default.
- W2332459367 cites W2112765785 @default.
- W2332459367 cites W2113972541 @default.
- W2332459367 cites W2121379361 @default.
- W2332459367 cites W2140058806 @default.
- W2332459367 cites W2140076005 @default.
- W2332459367 cites W2146568771 @default.
- W2332459367 cites W2154407429 @default.
- W2332459367 cites W2172299164 @default.
- W2332459367 cites W2331952397 @default.
- W2332459367 doi "https://doi.org/10.1021/mp400589q" @default.
- W2332459367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24446810" @default.
- W2332459367 hasPublicationYear "2014" @default.
- W2332459367 type Work @default.
- W2332459367 sameAs 2332459367 @default.
- W2332459367 citedByCount "12" @default.
- W2332459367 countsByYear W23324593672014 @default.
- W2332459367 countsByYear W23324593672016 @default.
- W2332459367 countsByYear W23324593672019 @default.
- W2332459367 countsByYear W23324593672020 @default.
- W2332459367 countsByYear W23324593672021 @default.
- W2332459367 countsByYear W23324593672022 @default.
- W2332459367 crossrefType "journal-article" @default.
- W2332459367 hasAuthorship W2332459367A5030272776 @default.
- W2332459367 hasAuthorship W2332459367A5048584299 @default.
- W2332459367 hasAuthorship W2332459367A5053639264 @default.
- W2332459367 hasAuthorship W2332459367A5060003459 @default.
- W2332459367 hasAuthorship W2332459367A5084633112 @default.
- W2332459367 hasConcept C100817775 @default.
- W2332459367 hasConcept C10389963 @default.
- W2332459367 hasConcept C147483822 @default.
- W2332459367 hasConcept C159654299 @default.
- W2332459367 hasConcept C185592680 @default.
- W2332459367 hasConcept C203014093 @default.
- W2332459367 hasConcept C2780801004 @default.
- W2332459367 hasConcept C2780868878 @default.
- W2332459367 hasConcept C2781253189 @default.
- W2332459367 hasConcept C501593827 @default.
- W2332459367 hasConcept C55493867 @default.
- W2332459367 hasConcept C86803240 @default.
- W2332459367 hasConcept C8891405 @default.
- W2332459367 hasConcept C89423630 @default.
- W2332459367 hasConceptScore W2332459367C100817775 @default.
- W2332459367 hasConceptScore W2332459367C10389963 @default.
- W2332459367 hasConceptScore W2332459367C147483822 @default.
- W2332459367 hasConceptScore W2332459367C159654299 @default.
- W2332459367 hasConceptScore W2332459367C185592680 @default.
- W2332459367 hasConceptScore W2332459367C203014093 @default.
- W2332459367 hasConceptScore W2332459367C2780801004 @default.
- W2332459367 hasConceptScore W2332459367C2780868878 @default.
- W2332459367 hasConceptScore W2332459367C2781253189 @default.
- W2332459367 hasConceptScore W2332459367C501593827 @default.
- W2332459367 hasConceptScore W2332459367C55493867 @default.
- W2332459367 hasConceptScore W2332459367C86803240 @default.
- W2332459367 hasConceptScore W2332459367C8891405 @default.
- W2332459367 hasConceptScore W2332459367C89423630 @default.
- W2332459367 hasIssue "3" @default.
- W2332459367 hasLocation W23324593671 @default.