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- W2332504168 abstract "Rationale: Multiple sclerosis (MS) is a chronic neurological disease of central nervous system (CNS) myelin. At present, there is no cure for MS due to the inability to repair damaged myelin. Although the neurotrophin, brain derived neurotrophic factor (BDNF) has a beneficial role in re-myelination and/or myelin repair, these effects can be hampered by over-expression of its transcriptional repressor methyl CpG binding protein 2 (MeCP2). We identified three novel biological targets that govern re-myelination and/or myelin repair including BDNF and the two biologically active isoforms of MeCP2: MeCP2E1 and MeCP2E2. However, their exact interactions are currently unknown." @default.
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- W2332504168 date "2014-10-01" @default.
- W2332504168 modified "2023-10-09" @default.
- W2332504168 title "Regulation of re-myelination and/or myelin repair by methyl CpG binding protein 2 and brain derived neurotrophic factor in an experimental autoimmune encephalomyelitis model of multiple sclerosis" @default.
- W2332504168 doi "https://doi.org/10.1016/j.jneuroim.2014.08.419" @default.
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