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- W2332510155 abstract "A major drawback from opioid therapy is tolerance development. Drugs acting on the serotonergic (5-HT) system have been studied to prevent this problem. The study examines the effect of chronic opioids on cerebral 5-HT2A receptors.Brain 5-HT2A receptor availability was estimated in seven healthy five-year-old female neutered Beagle dogs pre and post chronic morphine treatment (oral sustained release morphine 20 mg twice daily for ten days) with 123I-5-I-R-91150 (a 5-HT2A selective radioligand) and Single Photon Emission Computed Tomography (SPECT). Before and on the last day of morphine treatment, SPECT scans were performed 90 minutes after 123I-5-I-R91150 injection. Dogs were premedicated with dexmedetomidine (375 µg m-2 body surface area, IM). Anesthesia was induced with propofol (2.80 ± 0.63 mg kg-1 IV) and maintained with isoflurane in oxygen. 5-HT2A receptor binding indices (BI) for the frontal, parietal, temporal and occipital cortex and the subcortical region were calculated by semiquantification with the cerebellum (devoid of 5-HT2A receptors) as a reference region. Data were analyzed by mixed-model with treatment as fixed effect and dog as random effect.Chronic morphine treatment significantly (p ≤ 0.05) lowered 5-HT2A BI’s in the right and left frontal cortex, the right and left temporal cortex, the right and left parietal cortex, and the subcortical region.The decreased cerebral 5-HT2A receptor availability following chronic morphine treatment suggests an interaction between the opioid and serotonergic system, the exact nature of this interaction remains to be elucidated." @default.
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- W2332510155 date "2012-01-01" @default.
- W2332510155 modified "2023-09-24" @default.
- W2332510155 title "The influence of chronic morphine on the canine cerebral 5-HT2A receptor availability measured with SPECT" @default.
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